Abstract
The cardiovascular effects of dopamine were studied in the anesthetized dog. Small doses (2 to 4 µg/kg) of the amine had little or no cardiac effect and produced a slight pressor-depressor effect. With intermediate doses (8 to 16 µg/kg), increments in heart contractile force and heart rate occurred and the effects on blood pressure were more pronounced. At the highest doses studied (32 to 64 µg/kg), marked increments in heart contractile force, heart rate and arterial pressure were observed. Analysis of the depressor phase of dopamine action indicated that this hypotensive effect was not blocked by dichloroisoproterenol, Dibenzyline, atropine, hexamethonium, or antihistamines. Studies of the effects of dopamine in preparations with constantly perfused limbs suggested that the depressor action of dopamine is the result of a reflex or a central nervous system effect.
Footnotes
- Received November 21, 1962.
- Accepted January 2, 1963.
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