PT  - JOURNAL ARTICLE
AU  - McDonald, Robert H.
AU  - Goldberg, Leon I.
TI  - ANALYSIS OF THE CARDIOVASCULAR EFFECTS OF DOPAMINE IN THE DOG
DP  - 1963 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 60--66
VI  - 140
IP  - 1
4099  - http://jpet.aspetjournals.org/content/140/1/60.short
4100  - http://jpet.aspetjournals.org/content/140/1/60.full
SO  - J Pharmacol Exp Ther1963 Apr 01; 140
AB  - The cardiovascular effects of dopamine were studied in the anesthetized dog. Small doses (2 to 4 µg/kg) of the amine had little or no cardiac effect and produced a slight pressor-depressor effect. With intermediate doses (8 to 16 µg/kg), increments in heart contractile force and heart rate occurred and the effects on blood pressure were more pronounced. At the highest doses studied (32 to 64 µg/kg), marked increments in heart contractile force, heart rate and arterial pressure were observed. Analysis of the depressor phase of dopamine action indicated that this hypotensive effect was not blocked by dichloroisoproterenol, Dibenzyline, atropine, hexamethonium, or antihistamines. Studies of the effects of dopamine in preparations with constantly perfused limbs suggested that the depressor action of dopamine is the result of a reflex or a central nervous system effect.