Abstract
d-Lysergic acid diethylamide (LSD-25) and 2 d-bromolysergic acid diethylamide (BOL 180, a congener of LSD-25 devoid of CNS stimulant properties) were tested for their efficacy against apomorphine-induced emesis in dogs. In addition, LSD-25 was tested against emesis induced by emetine, Hydergine, morphine, ouabain and protoveratrine.
LSD-25 effectively antagonized apomorphine-induced emesis whereas BOL-180 showed no protective effect. LSD-25 also protected against vomiting evoked by morphine and Hydergine, but it was ineffective against emetine, ouabain and protoveratrine. These findings suggest that the mechanism of antiemetic action of LSD-25 is a selective depression of the medullary emetic chemoreceptor trigger zone.
Footnotes
- Received January 25, 1961.
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