TY - JOUR T1 - ANTIEMETIC ACTIVITY OF <em>D</em>-LYSERGIC ACID DIETHYLAMIDE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 137 LP - 139 VL - 133 IS - 1 AU - B. N. Dhawan AU - G. P. Gupta Y1 - 1961/07/01 UR - http://jpet.aspetjournals.org/content/133/1/137.abstract N2 - d-Lysergic acid diethylamide (LSD-25) and 2 d-bromolysergic acid diethylamide (BOL 180, a congener of LSD-25 devoid of CNS stimulant properties) were tested for their efficacy against apomorphine-induced emesis in dogs. In addition, LSD-25 was tested against emesis induced by emetine, Hydergine, morphine, ouabain and protoveratrine. LSD-25 effectively antagonized apomorphine-induced emesis whereas BOL-180 showed no protective effect. LSD-25 also protected against vomiting evoked by morphine and Hydergine, but it was ineffective against emetine, ouabain and protoveratrine. These findings suggest that the mechanism of antiemetic action of LSD-25 is a selective depression of the medullary emetic chemoreceptor trigger zone. ER -