RT Journal Article SR Electronic T1 ANTIEMETIC ACTIVITY OF D-LYSERGIC ACID DIETHYLAMIDE JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 137 OP 139 VO 133 IS 1 A1 B. N. Dhawan A1 G. P. Gupta YR 1961 UL http://jpet.aspetjournals.org/content/133/1/137.abstract AB d-Lysergic acid diethylamide (LSD-25) and 2 d-bromolysergic acid diethylamide (BOL 180, a congener of LSD-25 devoid of CNS stimulant properties) were tested for their efficacy against apomorphine-induced emesis in dogs. In addition, LSD-25 was tested against emesis induced by emetine, Hydergine, morphine, ouabain and protoveratrine. LSD-25 effectively antagonized apomorphine-induced emesis whereas BOL-180 showed no protective effect. LSD-25 also protected against vomiting evoked by morphine and Hydergine, but it was ineffective against emetine, ouabain and protoveratrine. These findings suggest that the mechanism of antiemetic action of LSD-25 is a selective depression of the medullary emetic chemoreceptor trigger zone.