Abstract

The urinary electrolyte pattern following aminophylline was similar to that of hydrochlorothiazide. Renal response to aminophylline was found to be independent of metabolic acidosis and probably augmented in metabolic alkalosis.

Aminophylline, hydrochlorothiazide and mercaptomerin had an additive effect on suppression of renal tubular reabsorption of Na⁺ and Cl^- when the latter two drugs were used in maximally effective doses. Thus, it appears that at least four different processes contribute to the mechanism(s) of Na⁺ and Cl^- reabsorption: one influenced by aminophylline, one by hydrochlorothiazide, one by mercurials and at least one or more not affected by any of these agents.