PT  - JOURNAL ARTICLE
AU  - Nechay, Bohdan R.
TI  - AMINOPHYLLINE AND ITS RELATIONSHIP TO SOME OTHER DIURETIC AGENTS IN DOGS
DP  - 1961 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 339--344
VI  - 132
IP  - 3
4099  - http://jpet.aspetjournals.org/content/132/3/339.short
4100  - http://jpet.aspetjournals.org/content/132/3/339.full
SO  - J Pharmacol Exp Ther1961 Jun 01; 132
AB  - The urinary electrolyte pattern following aminophylline was similar to that of hydrochlorothiazide. Renal response to aminophylline was found to be independent of metabolic acidosis and probably augmented in metabolic alkalosis. Aminophylline, hydrochlorothiazide and mercaptomerin had an additive effect on suppression of renal tubular reabsorption of Na+ and Cl- when the latter two drugs were used in maximally effective doses. Thus, it appears that at least four different processes contribute to the mechanism(s) of Na+ and Cl- reabsorption: one influenced by aminophylline, one by hydrochlorothiazide, one by mercurials and at least one or more not affected by any of these agents.