Abstract
Reserpine, in doses as high as 10 mgm./kgm., was found to have little effect upon the level of reflex excitability of the spinal cord in either spinal or decerebrate cats. Synaptic recovery, response to repetitive stimulation, and direct inhibition in the monosynaptic pathway were likewise unaffected by the drug.
Post-tetanic potentiation (PTP) in the monosynaptic pathway is markedly reduced by large doses (5 to 10 mgm./kgm.) of reserpine. This reduction is seen in both spinal and decerebrate cats and is attributable to the drug rather than to the vehicle. It remains to be shown that this effect upon spinal cord PTP is related to the characteristic effects of reserpine in intact animals.
Footnotes
- Received May 20, 1957.
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