Abstract

Inorganic sulfate, taurine, cysteamine and cystamine were demonstrated in the urine of normal and x-irradiated male mice receiving S³⁵-cysteamine. These findings corroborate reports of its degradation in rats. There appears to be no difference in the metabolism of this agent as a result of its presence during x-irradiation. Excretion of radioactivity, however, was significantly slower in the x-irradiated animal.

In man, as in the mouse, sulfate and taurine constituted the largest portion of the urinary excretory products. Several metabolites present in human urine were not seen in mouse urine. In man, the urinary end products differed under hypoxic conditions.