Abstract
1. Fifteen new antihistaminic drugs have been evaluated for their ability to cause closure of the precapillary sphincters of the mammalian capillary bed. Anthallan, chloroprophenpyridamine, 194-A, 194-C and Antergan were the most potent local vasoconstrictors tested by this method.
2. The vasoconstrictor effect produced by topical application of the anti-histaminics to the capillary bed was produced at concentrations which were of the same order of magnitude as those obtained in animals or humans after oral or intravenous administration.
3. The relationship between vasoconstrictor activity and chemical structure was discussed.
Footnotes
- Received July 31, 1950.
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