RT Journal Article
SR Electronic
T1 THE EFFECT OF SEVERAL NEW ANTIHISTAMINIC DRUGS UPON THE MAMMALIAN CAPILLARY BED
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 393
OP 397
VO 100
IS 4
A1 Haley, Thomas J.
A1 Andem, Margaret R.
YR 1950
UL http://jpet.aspetjournals.org/content/100/4/393.abstract
AB 1. Fifteen new antihistaminic drugs have been evaluated for their ability to cause closure of the precapillary sphincters of the mammalian capillary bed. Anthallan, chloroprophenpyridamine, 194-A, 194-C and Antergan were the most potent local vasoconstrictors tested by this method. 2. The vasoconstrictor effect produced by topical application of the anti-histaminics to the capillary bed was produced at concentrations which were of the same order of magnitude as those obtained in animals or humans after oral or intravenous administration. 3. The relationship between vasoconstrictor activity and chemical structure was discussed.