Abstract
A unique electron spin resonance, nitroxide spin-label probe technique is used to detect interaction between phenothiazine derivatives and bovine erythrocyte ghost membranes. Effects of solubilizing agents before and after reacting the spin label with the ghosts indicate that at least three membrane sulfhydryl sites can be spin labeled. Druginduced changes in electron spin resonance spectra from the spin-labeled membranes suggest that the drugs alter the protein structure of one of the spin-labeled sites.
Footnotes
- Received September 29, 1969.
- Accepted December 16, 1969.
- © 1970, by The Williams & Wilkins Company
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