RT Journal Article
SR Electronic
T1 EFFECTS OF PHENOTHIAZINE DERIVATIVES ON BIOLOGICAL MEMBRANES: DRUG-INDUCED CHANGES IN ELECTRON SPIN RESONANCE SPECTRA FROM SPIN-LABELED ERYTHROCYTE GHOST MEMBRANES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 78
OP 84
VO 173
IS 1
A1 HOLMES, D. E.
A1 PIETIE, L. H.
YR 1970
UL http://jpet.aspetjournals.org/content/173/1/78.abstract
AB A unique electron spin resonance, nitroxide spin-label probe technique is used to detect interaction between phenothiazine derivatives and bovine erythrocyte ghost membranes. Effects of solubilizing agents before and after reacting the spin label with the ghosts indicate that at least three membrane sulfhydryl sites can be spin labeled. Druginduced changes in electron spin resonance spectra from the spin-labeled membranes suggest that the drugs alter the protein structure of one of the spin-labeled sites. © 1970, by The Williams & Wilkins Company