PT  - JOURNAL ARTICLE
AU  - HOLMES, D. E.
AU  - PIETIE, L. H.
TI  - EFFECTS OF PHENOTHIAZINE DERIVATIVES ON BIOLOGICAL MEMBRANES: DRUG-INDUCED CHANGES IN ELECTRON SPIN RESONANCE SPECTRA FROM SPIN-LABELED ERYTHROCYTE GHOST MEMBRANES
DP  - 1970 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 78--84
VI  - 173
IP  - 1
4099  - http://jpet.aspetjournals.org/content/173/1/78.short
4100  - http://jpet.aspetjournals.org/content/173/1/78.full
SO  - J Pharmacol Exp Ther1970 May 01; 173
AB  - A unique electron spin resonance, nitroxide spin-label probe technique is used to detect interaction between phenothiazine derivatives and bovine erythrocyte ghost membranes. Effects of solubilizing agents before and after reacting the spin label with the ghosts indicate that at least three membrane sulfhydryl sites can be spin labeled. Druginduced changes in electron spin resonance spectra from the spin-labeled membranes suggest that the drugs alter the protein structure of one of the spin-labeled sites. © 1970, by The Williams & Wilkins Company