Abstract
The uptake of a series of tritium-labeled methonium compounds in the central nervous system of adult Sprague-Dawley rats was investigated. Central nervous system tissue showed higher affinity for those methonium compounds with longer methylene chains. This differential drug uptake appeared to be unrelated to plasma radioactivity measured 4 hr after i.m. injections. Histologic localization of tritiated hexamethonium and decamethonium was undertaken using autoradiography. Radioactivity was associated with cells forming the choroid plexuses and the arachnoid (or "pia-arachnoid" in areas where histologic resolution was inconclusive). The remainder of the tissue sections appeared devoid of radioactivity. Possible routes of access of these drugs to cells of the choroid plexuses and arachnoid have been discussed, and the significance of the present findings to other in vivo and in vitro uptake studies has been noted.
Footnotes
- Received August 8, 1968.
- Accepted December 17, 1968.
- © 1969, by The Williams & Wilkins Company
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