RT Journal Article
SR Electronic
T1 UPTAKE AND DISTRIBUTION OF SOME QUATERNARY AMMONIUM COMPOUNDS IN THE CENTRAL NERVOUS SYSTEM OF THE RAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 56
OP 62
VO 167
IS 1
A1 GOSLING, J. A.
A1 LU, T. C.
YR 1969
UL http://jpet.aspetjournals.org/content/167/1/56.abstract
AB The uptake of a series of tritium-labeled methonium compounds in the central nervous system of adult Sprague-Dawley rats was investigated. Central nervous system tissue showed higher affinity for those methonium compounds with longer methylene chains. This differential drug uptake appeared to be unrelated to plasma radioactivity measured 4 hr after i.m. injections. Histologic localization of tritiated hexamethonium and decamethonium was undertaken using autoradiography. Radioactivity was associated with cells forming the choroid plexuses and the arachnoid (or "pia-arachnoid" in areas where histologic resolution was inconclusive). The remainder of the tissue sections appeared devoid of radioactivity. Possible routes of access of these drugs to cells of the choroid plexuses and arachnoid have been discussed, and the significance of the present findings to other in vivo and in vitro uptake studies has been noted. © 1969, by The Williams & Wilkins Company