Abstract
Imidazoleacetylcholine (ImACh) has been compared with imidazoleacrylcholine (ImAcrCh) and imidazolepropionylcholine (ImPrCh) in some enzymic and pharmacologic studies. As with ImAerCh and ImPrCh, ImACh causes neuromuscular blockade, stimulates ganglia, weakly stimulates the peripheral cholinergic effector sites, potentiates histamine, causes contracture of the frog rectus abdominis muscle, inhibits cholinesterases and diamine oxidase and is hydrolyzed by some nonspecific cholinesterases. In general, the order of activity is ImPrCh 〉 ImAerCh 〉 ImACh.
The ganglionic stimulation, peripheral cholinergic stimulation and frog rectus actions are blocked by hexamethonium, atropine and d-tubocurarine, respectively.
Footnotes
- Received December 11, 1957.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement