RT Journal Article
SR Electronic
T1 ENZYMIC AND PHARMACOLOGIC COMPARISON OF IMIDAZOLEACETYLCHOLINE WITH TWO RELATED CHOLINE ESTERS, MUREXINE AND DIHYDROMUREXINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 98
OP 103
VO 123
IS 2
A1 Tabachnick, I. I. A.
A1 Roth, F. E.
A1 Mershon, J.
A1 Rubin, A. A.
A1 Eckhardt, E. T.
A1 Govier, W. M.
YR 1958
UL http://jpet.aspetjournals.org/content/123/2/98.abstract
AB Imidazoleacetylcholine (ImACh) has been compared with imidazoleacrylcholine (ImAcrCh) and imidazolepropionylcholine (ImPrCh) in some enzymic and pharmacologic studies. As with ImAerCh and ImPrCh, ImACh causes neuromuscular blockade, stimulates ganglia, weakly stimulates the peripheral cholinergic effector sites, potentiates histamine, causes contracture of the frog rectus abdominis muscle, inhibits cholinesterases and diamine oxidase and is hydrolyzed by some nonspecific cholinesterases. In general, the order of activity is ImPrCh 〉 ImAerCh 〉 ImACh. The ganglionic stimulation, peripheral cholinergic stimulation and frog rectus actions are blocked by hexamethonium, atropine and d-tubocurarine, respectively.