Abstract

A technique has been devised to screen potential ataraxic agents by their ability to protect against audiogenic seizures in mice. Comparative standards were established by use of chlorpromazine, reserpine and meprobamate.

NC 1318, 1428, 1457, 1540 and 1541, a group of new hemiacetals, all proved effective antagonists of audiogenic seizures in mice. Of these, the most potent was NC 1457; chemically, (2,2,2-trichloro-1-[1-ethyl-1-methyl-(2-propyne-1-oxy)] ethanol).