Journal of Pharmacology and Experimental Therapeutics: 296 (2)

February 01, 2001; Volume 296,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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The Biochemical and Neurologic Basis for the Treatment of Male Erectile Dysfunction
Robert B. Moreland, Gin Hsieh, Masaki Nakane and Jorge D. Brioni

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 225-234;

CELLULAR AND MOLECULAR

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Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates
James E. Dunford, Keith Thompson, Fraser P. Coxon, Steven P. Luckman, Frederick M. Hahn, C. Dale Poulter, Frank H. Ebetino and Michael J. Rogers

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 235-242;
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The Binding-Site Crevice of the D₄ Dopamine Receptor Is Coupled to Three Distinct Sites of Allosteric Modulation
John A. Schetz and David R. Sibley

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 359-363;
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Regulation of Ornithine Decarboxylase Activity and Polyamine Transport by Agmatine in Rat Pulmonary Artery Endothelial Cells
Pavel Babál, Mykhaylo Ruchko, Clayton C. Campbell, Susan P. Gilmour, John L. Mitchell, Jack W. Olson and Mark N. Gillespie

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 372-377;
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Differential Sensitivity of Kv1.4, Kv1.2, and Their Tandem Channel to Acidic pH: Involvement of a Histidine Residue in High Sensitivity to Acidic pH
Kuniaki Ishii, Kazuo Nunoki, Toshio Yamagishi, Hitoshi Okada and Norio Taira

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 405-411;
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In Vitro and in Vivo Pharmacological Characterization of JTE-907, a Novel Selective Ligand for Cannabinoid CB₂ Receptor
Hiroyuki Iwamura, Hidekazu Suzuki, Yoshifumi Ueda, Tetsudo Kaya and Takashi Inaba

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 420-425;
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The Thromboxane A2 Receptor Activates Mitogen-Activated Protein Kinase via Protein Kinase C-Dependent Gi Coupling and Src-Dependent Phosphorylation of the Epidermal Growth Factor Receptor
Yunling Gao, Shaoqing Tang, Sharon Zhou and J. Anthony Ware

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 426-433;
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A Common Mechanism for Cystic Fibrosis Transmembrane Conductance Regulator Protein Activation by Genistein and Benzimidazolone Analogs
Layla Al-Nakkash, Shenghui Hu, Min Li and Tzyh-Chang Hwang

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 464-472;
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Regulation of Thromboxane Receptor (TP) Phosphorylation by Protein Phosphatase 1 (PP1) and PP2A
Robert F. Spurney

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 592-599;

TOXICOLOGY

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Biochemical and Functional Characteristics of Cultured Renal Epithelial Cells from Uninephrectomized Rats: Factors Influencing Nephrotoxicity
Lawrence H. Lash, David A. Putt and Rudolfs K. Zalups

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 243-251;
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Metabolic Capabilities of CYP2F2 with Various Pulmonary Toxicants and Its Relative Abundance in Mouse Lung Subcompartments
Michael A. Shultz, Dexter Morin, Ai-Min Chang and Alan Buckpitt

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 510-519;

CARDIOVASCULAR

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Evidence for Inducible Nitric-Oxide Synthase Expression and Activity in Vascular Smooth Muscle of Streptozotocin-Diabetic Rats
Andrea L. Bardell and Kathleen M. MacLeod

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 252-259;
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Regional Differences in Anandamide- and Methanandamide-Induced Membrane Potential Changes in Rat Mesenteric Arteries
Bert Vanheel and Johan Van de Voorde

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 322-328;
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Effects of Salt Intake and Angiotensin II on Vascular Reactivity to Endothelin-1
Jennifer R. Ballew, Stephanie W. Watts and Gregory D. Fink

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 345-350;
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Signaling Mechanisms for the Selective Vasoconstrictor Effect of Norbormide on the Rat Small Arteries
S. Bova, L. Trevisi, L. Cima, S. Luciani, V. Golovina and G. Cargnelli

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 458-463;
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Vascular Endothelial Growth Factor-Mediated Endothelium-Dependent Relaxation Is Blunted in Spontaneously Hypertensive Rats
Ming-Hui Liu, Hong-Kui Jin, H. Storm Floten, Qin Yang, Anthony P. C. Yim, Anthony Furnary, Thomas F. Zioncheck, Stuart Bunting and Guo-Wei He

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 473-477;
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Differential Localization of P2 Receptor Subtypes in Mesenteric Arteries and Veins of Normotensive and Hypertensive Rats
James J. Galligan, Margaret C. Hess, Sara B. Miller and Gregory D. Fink

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 478-485;
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A Novel Synthetic Inhibitor of Factor Xa Decreases Early Reocclusion and Improves 24-h Patency after Coronary Fibrinolysis in Dogs
Dana R. Abendschein, Pamela K. Baum, Peter Verhallen, Paul R. Eisenberg, Mark E. Sullivan and David R. Light

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 567-572;
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Effects of Bupivacaine and a Novel Local Anesthetic, IQB-9302, on Human Cardiac K⁺ Channels
Teresa González, Mónica Longobardo, Ricardo Caballero, Eva Delpón, Juan Tamargo and Carmen Valenzuela

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 573-583;
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Differential Activation of Extracellular Signal Regulated Kinase Isoforms in Preconditioning and Opioid-Induced Cardioprotection
Ryan M. Fryer, Phillip F. Pratt, Anna K. Hsu and Garrett J. Gross

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 642-649;

NEUROPHARMACOLOGY

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Evidence of a Functional α7-Neuronal Nicotinic Receptor Subtype Located on Motoneurons of the Dorsal Motor Nucleus of the Vagus
Manuel Ferreira, Steven N. Ebert, David C. Perry, Robert P. Yasuda, Chandra M. Baker, Martha I. Dávila-García, Kenneth J. Kellar and Richard A. Gillis

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 260-269;
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Gabapentin Antinociception in Mice with Acute Herpetic Pain Induced by Herpes Simplex Virus Infection
Ichiro Takasaki, Tsugunobu Andoh, Hiroshi Nojima, Kimiyasu Shiraki and Yasushi Kuraishi

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 270-275;
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Effective Plasma Concentration of a Novel Na⁺/Ca²⁺ Channel Blocker NS-7 for Its Cerebroprotective Actions in Rats with a Transient Middle Cerebral Artery Occlusion
Yasuaki Aoki, Masaru Tamura, Yoshinori Itoh, Toshie Seto, Kiyoko Nonaka, Hideya Mukai and Yojiro Ukai

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 306-311;
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SB 239063, a Second-Generation p38 Mitogen-Activated Protein Kinase Inhibitor, Reduces Brain Injury and Neurological Deficits in Cerebral Focal Ischemia
F. C. Barone, E. A. Irving, A. M. Ray, J. C. Lee, S. Kassis, S. Kumar, A. M. Badger, R. F. White, M. J. McVey, J. J. Legos, J. A. Erhardt, A. H. Nelson, E. H. Ohlstein, A. J. Hunter, K. Ward, B. R. Smith, J. L. Adams and A. A. Parsons

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 312-321;
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Dinapsoline: Characterization of a D₁ Dopamine Receptor Agonist in a Rat Model of Parkinson's Disease
Amit G. Gulwadi, Carolyn D. Korpinen, Richard B. Mailman, David E. Nichols, Sing-Yuen Sit and Matthew T. Taber

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 338-344;
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Drug Interactions with the Dopamine Transporter in Cryopreserved Human Caudate
Amy J. Eshleman, Katherine Wolfrum, Deborah C. Mash, Kevin Christensen and Aaron Janowsky

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 442-449;
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Intravenous Nicotine and Caffeine: Subjective and Physiological Effects in Cocaine Abusers
Bridgette E. Garrett and Roland R. Griffiths

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 486-494;
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Long-Term Changes in Basal Ganglia Function after a Neurotoxic Regimen of Methamphetamine
David E. Chapman, Glen R. Hanson, Raymond P. Kesner and Kristen A. Keefe

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 520-527;
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Pharmacokinetic and Pharmacodynamic Evaluations of a Potent Analgesic, Dihydroetorphine, in Hairless Rat
Satoshi Ohmori, Teruaki Hayashi, Masami Kawase, Setsuo Saito and Yasunori Morimoto

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 528-536;
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Bradykinin Modulation of Tumor Vasculature: I. Activation of B₂ Receptors Increases Delivery of Chemotherapeutic Agents into Solid Peripheral Tumors, Enhancing Their Efficacy
Dwaine F. Emerich, Pamela Snodgrass, Reginald L. Dean, Denise Lafreniere, Mary Agostino, Tania Wiens, Hua Xiong, Brant Hasler, Joanne Marsh, Melissa Pink, Byong Su Kim and Raymond T. Bartus

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 623-631;
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Bradykinin Modulation of Tumor Vasculature: II. Activation of Nitric Oxide and Phospholipase A₂/Prostaglandin Signaling Pathways Synergistically Modifies Vascular Physiology and Morphology to Enhance Delivery of Chemotherapeutic Agents to Tumors
Dwaine F. Emerich, Reginald L. Dean, Pamela Snodgrass, Denise Lafreniere, Mary Agostino, Tania Wiens, Hua Xiong, Brant Hasler, Joanne Marsh, Melissa Pink, Byong Su Kim, Brigido Perdomo and Raymond T. Bartus

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 632-641;
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Pharmacological Properties of the Potent Epileptogenic Amino Acid Dysiherbaine, a Novel Glutamate Receptor Agonist Isolated from the Marine Sponge Dysidea herbacea
Ryuichi Sakai, Geoffrey T. Swanson, Keiko Shimamoto, Tim Green, Anis Contractor, Andrea Ghetti, Yoshiko Tamura-Horikawa, Chie Oiwa and Hisao Kamiya

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 650-658;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Apoptotic Events in a Human Ovarian Cancer Cell Line Exposed to Anthracyclines
Daniela Bellarosa, Alessandra Ciucci, Angela Bullo, Federica Nardelli, Stefano Manzini, Carlo Alberto Maggi and Cristina Goso

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 276-283;
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Antimitotic Actions of a Novel Analog of the Fungal Metabolite Palmarumycin CP₁
John S. Lazo, Kenji Tamura, Andreas Vogt, Jae-Kyu Jung, Sonia Rodriguez, Raghavan Balachandran, Billy W. Day and Peter Wipf

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 364-371;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Trimellitic Anhydride-Induced Allergic Response in the Guinea Pig Lung Involves Antibody-Dependent and -Independent Complement System Activation
Christen P. Larsen, Ronald R. Regal and Jean F. Regal

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 284-292;
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Intestinal Inflammation Enhances the Inhibitory Effects of Opioids on Intestinal Permeability in Mice
Lluı́s Valle, Olga Pol and Margarita M. Puig

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 378-387;
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RETRACTION: Pre- or Post-Ischemic Treatment with a Novel Na⁺/Ca²⁺ Exchange Inhibitor, KB-R7943, Shows Renal Protective Effects in Rats with Ischemic Acute Renal Failure
Junji Yamashita, Makoto Itoh, Toshihiko Kuro, Yutaka Kobayashi, Masaya Ogata, Masanori Takaoka and Yasuo Matsumura

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 412-419;
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Effects of Isoprostanes and Prostanoids on Porcine Small Intestine
Martin Andreas Unmack, Patangi K. Rangachari and Erik Skadhauge

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 434-441;
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Benzimidazolone Activators of Chloride Secretion: Potential Therapeutics for Cystic Fibrosis and Chronic Obstructive Pulmonary Disease
Sangeeta Singh, Colin A. Syme, Ashvani K. Singh, Daniel C. Devor and Robert J. Bridges

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 600-611;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Synthesis of 5-Oxo-6,8,11,14-eicosatetraenoic Acid and Identification of Novel ω-Oxidized Metabolites in the Mouse Macrophage
John M. Hevko, Rebecca C. Bowers and Robert C. Murphy

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 293-305;
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Modulation of P450 CYP3A4-Dependent Metabolism by P-glycoprotein: Implications for P450 Phenotyping
Jens M. Baron, Lay Beng Goh, Denggao Yao, C. Roland Wolf and Thomas Friedberg

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 351-358;
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Pharmacokinetics and Pharmacodynamics of an Antisense Phosphorothioate Oligonucleotide Targeting Fas mRNA in Mice
Rosie Z. Yu, Hong Zhang, Richard S. Geary, Mark Graham, Lilit Masarjian, Kristina Lemonidis, Rosanne Crooke, Nicholas M. Dean and Arthur A. Levin

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 388-395;
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Characterization of a Novel Cationic Drug Transporter in Human Retinal Pigment Epithelial Cells
Yong-Hae Han, Douglas H. Sweet, Dan-Ning Hu and John B. Pritchard

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 450-457;
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Human CYP1B1 and Anticancer Agent Metabolism: Mechanism for Tumor-Specific Drug Inactivation?
Bertrand Rochat, Janine M. Morsman, Graeme I. Murray, William D. Figg and Howard L. McLeod

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 537-541;
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Molecular Cloning and Regulation of Expression of Two Novel Mouse CYP4F Genes: Expression in Peroxisome Proliferator-Activated Receptor α-Deficient Mice upon Lipopolysaccharide and Clofibrate Challenges
Xiaoming Cui, Hidenori Kawashima, Thomas B. Barclay, Jeffrey M. Peters, Frank J. Gonzalez, Edward T. Morgan and Henry W. Strobel

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 542-550;
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Pluronic P85 Enhances the Delivery of Digoxin to the Brain: In Vitro and in Vivo Studies
Elena V. Batrakova, Donald W. Miller, Shu Li, Valery Yu Alakhov, Alexander V. Kabanov and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 551-557;
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Kinetic Profiling of P-glycoprotein-Mediated Drug Efflux in Rat and Human Intestinal Epithelia
R. H. Stephens, C. A. O'Neill, A. Warhurst, G. L. Carlson, M. Rowland and G. Warhurst

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 584-591;
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Kinetics of Monochloroacetic Acid in Adult Male Rats after Intravenous Injection of a Subtoxic and a Toxic Dose
Shakil A. Saghir, Kristian Fried and Karl K. Rozman

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 612-622;

ENDOCRINE AND REPRODUCTIVE

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Assessment of the Effects of Metabolism on the Estrogenic Activity of Xenoestrogens: A Two-Stage Approach Coupling Human Liver Microsomes and a Yeast Estrogenicity Assay
Robert Elsby, James L. Maggs, John Ashby, David Paton, John P. Sumpter and B. Kevin Park

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 329-337;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Pharmacokinetics and Immunological Effects of Exogenously Administered Recombinant Human B Lymphocyte Stimulator (BLyS) in Mice
Tom J. Parry, Todd A. Riccobene, Steven J. Strawn, Rita Williams, Rami Daoud, Jeffrey Carrell, Svetlana Sosnovtseva, Renée C. Miceli, Carol M. Poortman, Les Sekut, Yuling Li, James Fikes and Cynthia Sung

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 396-404;
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Anti-Inflammatory Effects of ABT-702, a Novel Non-Nucleoside Adenosine Kinase Inhibitor, in Rat Adjuvant Arthritis
David L. Boyle, Elizabeth A. Kowaluk, Michael F. Jarvis, Chih-Hung Lee, Shripad S. Bhagwat, Michael Williams and Gary S. Firestein

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 495-500;
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Effects of A-134974, a Novel Adenosine Kinase Inhibitor, on Carrageenan-Induced Inflammatory Hyperalgesia and Locomotor Activity in Rats: Evaluation of the Sites of Action
Steve McGaraughty, Katharine L. Chu, Carol T. Wismer, Joe Mikusa, Chang Z. Zhu, Marlon Cowart, Elizabeth A. Kowaluk and Michael F. Jarvis

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 501-509;
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Etoricoxib (MK-0663): Preclinical Profile and Comparison with Other Agents That Selectively Inhibit Cyclooxygenase-2
D. Riendeau, M. D. Percival, C. Brideau, S. Charleson, D. Dubé, D. Ethier, J.-P. Falgueyret, R. W. Friesen, R. Gordon, G. Greig, J. Guay, J. Mancini, M. Ouellet, E. Wong, L. Xu, S. Boyce, D. Visco, Y. Girard, P. Prasit, R. Zamboni, I. W. Rodger, M. Gresser, A. W. Ford-Hutchinson, R. N. Young and C.-C. Chan

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 558-566;

ASPET MEETING REPORT

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Glutamate 2000: Old Dog, New Tricks
Robert Schwarcz

Journal of Pharmacology and Experimental Therapeutics February 2001, 296 (2) 659-667;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

CELLULAR AND MOLECULAR

TOXICOLOGY

CARDIOVASCULAR

NEUROPHARMACOLOGY

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

ENDOCRINE AND REPRODUCTIVE

INFLAMMATION AND IMMUNOPHARMACOLOGY

ASPET MEETING REPORT

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