Abstract
The monoamine oxidase inhibitors, tranylcypromine, phenylisopropylhydrazmne, MO 911, ethyltryptamine, harmaline, amphetamine and methamphetamine all produced a reversible block of neuromyal transmission in the isolated rat phrenic nerve-diaphragm preparation. They did not block when application was restricted to the nerve and they increased the force of contraction of directly stimulated muscle. They did block the action of acetylcholine on the denervated diaphragm. It is concluded that these compounds block transmission by a mechanism not involving inhibition of monoamine oxidase.
Footnotes
- Received November 16, 1962.
- Accepted February 7, 1963.
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