Abstract
Cardioactive metabolites as well as the free glycosides have been detected in the heart, liver, kidney, and circulating blood of the rat, immediately following the injection of digoxin and lanatoside C. The metabolites were the same as those found in urine. Digitoxin and its metabolite, previously found in rat urine, were detected in rat livers immediately after injection, but only the free glycoside could be detected in blood and kidney. Using chemical techniques only, no trace of digitoxin could be found in the heart.
The main portion of the dose of the glycosides is quickly removed from the blood, digitoxin most rapidly, followed by lanatoside C and digoxin. No trace of any cardioactive genin could be detected in any tissue after administration of these glycosides and when digitoxigenin was injected it produced a metabolite in the liver which differed from that formed from digitoxin.
Footnotes
- Received April 24, 1956.
- 1956 by The American Society for Pharmacology and Experimental Therapeutics
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