Abstract
Sodium fluoroacetate inhibits the spontaneous contractions of intestinal smooth muscle. This effect is quantitatively and qualitatively different when different types of substrate are used. Complete inhibition of spontaneous contractions does not occur in the presence of glucose or mannose. Inhibition of spontaneous contractions is complete in the presence of acetate, pyruvate, oxalacetate, acetoacetic acid and a number of fatty acids as substrates.
Strips of the large intestine are more resistant to NaFAc than those of the small intestine.
The fluoroacetate resistant contractions occurring in the presence of glucose are abolished by iodoacetate, p-chloromercuribenzoate, dinitrophenol and sodium azide. They are not abolished by anaerobiosis, sodium cyanide, malonic and propionic acid. Under aerobic conditions and in the presence of substrate the effects of NaFAc are not reversed by repeated washing with Tyrode solution.
Footnotes
- Received November 1, 1949.
- 1950 by The American Society for Pharmacology and Experimental Therapeutics
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