Abstract
1. Methods are described for the estimation of procaine and its transformation products in biological fluids and tissues in vivo.
2. The first step in the metabolism of procaine after its intravenous administration to man was shown to be hydrolysis to diethylaminoethanol and p-aminobenzoic acid. The hydrolysis takes place with unusual rapidity. Diethylaminoethanol is further metabolized in large part, but the nature of its transformation is not known.
3. The hydrolysis of procaine occurs mainly in the plasma.
Footnotes
- Received August 11, 1948.
- 1948 by The American Society for Pharmacology and Experimental Therapeutics
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement