Abstract
1. A small dose of physostigmine given to cats protects against the fatal action of a subsequent dose of DFP (di-isopropyl fluorophosphate).
2. Repeated injections of physostigmine do not significantly increase tolerance.
3. DFP results in a long lasting increase in the susceptibility of cats to the lethal action of physostigmine. This result of DFP is much less pronounced in cats protected by physostigmine.
4. The cholinesterase activity of the serum from animals pre-treated with physostigmine shows a smaller reduction than serum from animals receiving DFP alone, and recovery is more rapid.
Footnotes
- Received May 16, 1946.
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