Dopamine’s interaction with dopamine receptors has the potential to trigger the translocation of nuclear factor kappa-light-chain-enhancer of B cells (NF-κB) to the nucleus, leading to an upregulation in the transcription and translation of inflammasome adaptor proteins (ASC or PYCARD) as well as pro-IL-1β. As multiple PYCARDs are recruited, inflammasomes are assembled, and with the presence of a secondary stimulant, they become activated. This activation culminates in the secretion of IL-1β and IL-18 from macrophages.