Clinical Pharmacology Modeling and Simulation, Amgen Inc., Thousand Oaks, California (I.V.); Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota (E.E.P.); Department of Neurology, University of California Davis School of Medicine, Sacramento, California (C.-Y.W., D.Z., M.A.R.); Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota (I.E.L., J.C.C., L.D.C.); and Department of Neurology, Mayo Clinic, Rochester, Minnesota (G.A.W., V.K.)

Clinical Pharmacology Modeling and Simulation, Amgen Inc., Thousand Oaks, California (I.V.); Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota (E.E.P.); Department of Neurology, University of California Davis School of Medicine, Sacramento, California (C.-Y.W., D.Z., M.A.R.); Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota (I.E.L., J.C.C., L.D.C.); and Department of Neurology, Mayo Clinic, Rochester, Minnesota (G.A.W., V.K.)

Clinical Pharmacology Modeling and Simulation, Amgen Inc., Thousand Oaks, California (I.V.); Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota (E.E.P.); Department of Neurology, University of California Davis School of Medicine, Sacramento, California (C.-Y.W., D.Z., M.A.R.); Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota (I.E.L., J.C.C., L.D.C.); and Department of Neurology, Mayo Clinic, Rochester, Minnesota (G.A.W., V.K.)

Clinical Pharmacology Modeling and Simulation, Amgen Inc., Thousand Oaks, California (I.V.); Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota (E.E.P.); Department of Neurology, University of California Davis School of Medicine, Sacramento, California (C.-Y.W., D.Z., M.A.R.); Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota (I.E.L., J.C.C., L.D.C.); and Department of Neurology, Mayo Clinic, Rochester, Minnesota (G.A.W., V.K.)

Clinical Pharmacology Modeling and Simulation, Amgen Inc., Thousand Oaks, California (I.V.); Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota (E.E.P.); Department of Neurology, University of California Davis School of Medicine, Sacramento, California (C.-Y.W., D.Z., M.A.R.); Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota (I.E.L., J.C.C., L.D.C.); and Department of Neurology, Mayo Clinic, Rochester, Minnesota (G.A.W., V.K.)

Clinical Pharmacology Modeling and Simulation, Amgen Inc., Thousand Oaks, California (I.V.); Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota (E.E.P.); Department of Neurology, University of California Davis School of Medicine, Sacramento, California (C.-Y.W., D.Z., M.A.R.); Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota (I.E.L., J.C.C., L.D.C.); and Department of Neurology, Mayo Clinic, Rochester, Minnesota (G.A.W., V.K.)

Clinical Pharmacology Modeling and Simulation, Amgen Inc., Thousand Oaks, California (I.V.); Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota (E.E.P.); Department of Neurology, University of California Davis School of Medicine, Sacramento, California (C.-Y.W., D.Z., M.A.R.); Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota (I.E.L., J.C.C., L.D.C.); and Department of Neurology, Mayo Clinic, Rochester, Minnesota (G.A.W., V.K.)

Clinical Pharmacology Modeling and Simulation, Amgen Inc., Thousand Oaks, California (I.V.); Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota (E.E.P.); Department of Neurology, University of California Davis School of Medicine, Sacramento, California (C.-Y.W., D.Z., M.A.R.); Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota (I.E.L., J.C.C., L.D.C.); and Department of Neurology, Mayo Clinic, Rochester, Minnesota (G.A.W., V.K.)

Clinical Pharmacology Modeling and Simulation, Amgen Inc., Thousand Oaks, California (I.V.); Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota (E.E.P.); Department of Neurology, University of California Davis School of Medicine, Sacramento, California (C.-Y.W., D.Z., M.A.R.); Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota (I.E.L., J.C.C., L.D.C.); and Department of Neurology, Mayo Clinic, Rochester, Minnesota (G.A.W., V.K.)

Clinical Pharmacology Modeling and Simulation, Amgen Inc., Thousand Oaks, California (I.V.); Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota (E.E.P.); Department of Neurology, University of California Davis School of Medicine, Sacramento, California (C.-Y.W., D.Z., M.A.R.); Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota (I.E.L., J.C.C., L.D.C.); and Department of Neurology, Mayo Clinic, Rochester, Minnesota (G.A.W., V.K.)