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Research ArticleDrug Discovery and Translational Medicine

Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates

Steven M. Weldon, Matthew A. Cerny, Kristina Gueneva-Boucheva, Derek Cogan, Xin Guo, Neil Moss, Jean-Hugues Parmentier, Jeremy R. Richman, Glenn A. Reinhart and Nicholas F. Brown
Journal of Pharmacology and Experimental Therapeutics October 2016, 359 (1) 142-150; DOI: https://doi.org/10.1124/jpet.116.236463

Article Information

vol. 359 no. 1 142-150
DOI 
https://doi.org/10.1124/jpet.116.236463
PubMed 
27481775
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received July 6, 2016
  • Accepted July 29, 2016
  • Published online September 8, 2016.

Article Versions

Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Steven M. Weldon,
  2. Matthew A. Cerny,
  3. Kristina Gueneva-Boucheva,
  4. Derek Cogan,
  5. Xin Guo,
  6. Neil Moss,
  7. Jean-Hugues Parmentier,
  8. Jeremy R. Richman,
  9. Glenn A. Reinhart, and
  10. Nicholas F. Brown
  1. CardioMetabolic Diseases Research (S.M.W., J-H. P., J.R.R., G.A.R., N.F.B.), and Medicinal Chemistry (M.A.C., K.G.B., D.C., X.G., N.M.), Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut
  1. Address correspondence to:
    Dr. Steven M. Weldon, Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals Inc., 175 Briar Ridge Road, Ridgefield, CT 06877. E-mail: steven.weldon{at}boehringer-ingelheim.com
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Research ArticleDrug Discovery and Translational Medicine

Selectivity of BI 689648, FAD286, and LCI699 in NHPs

Steven M. Weldon, Matthew A. Cerny, Kristina Gueneva-Boucheva, Derek Cogan, Xin Guo, Neil Moss, Jean-Hugues Parmentier, Jeremy R. Richman, Glenn A. Reinhart and Nicholas F. Brown
Journal of Pharmacology and Experimental Therapeutics October 1, 2016, 359 (1) 142-150; DOI: https://doi.org/10.1124/jpet.116.236463
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