Research ArticleDrug Discovery and Translational Medicine
New Multi-target Antagonists of α1A-, α1D-Adrenoceptors and 5-HT1A Receptors Reduce Human Hyperplastic Prostate Cell Growth and the Increase of Intraurethral Pressure
Jéssica B. Nascimento-Viana, Aline R. Carvalho, Luiz Eurico Nasciutti, Rocío Alcántara-Hernández, Fernanda Chagas-Silva, Pedro A. R. Souza, Luiz Antonio S. Romeiro, J. Adolfo García-Sáinz, François Noël and Claudia Lucia Martins Silva
Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 212-222; DOI: https://doi.org/10.1124/jpet.115.227066
Jéssica B. Nascimento-Viana
Laboratory of Molecular and Biochemical Pharmacology (J.B.N.-V., A.R.C., F.C.-S., F.N., C.L.M.S.) and Cell Biology and Development Research Program (P.A.R.S., L.E.N.), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Cell Physiology Institute, Universidad Nacional Autónoma de México, D.F., Mexico (R.A.-H., J.A.G.-S.); and Pharmaceutical Sciences, Universidade de Brasília, Brasília, Brazil (L.A.S.R.)
Aline R. Carvalho
Laboratory of Molecular and Biochemical Pharmacology (J.B.N.-V., A.R.C., F.C.-S., F.N., C.L.M.S.) and Cell Biology and Development Research Program (P.A.R.S., L.E.N.), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Cell Physiology Institute, Universidad Nacional Autónoma de México, D.F., Mexico (R.A.-H., J.A.G.-S.); and Pharmaceutical Sciences, Universidade de Brasília, Brasília, Brazil (L.A.S.R.)
Luiz Eurico Nasciutti
Laboratory of Molecular and Biochemical Pharmacology (J.B.N.-V., A.R.C., F.C.-S., F.N., C.L.M.S.) and Cell Biology and Development Research Program (P.A.R.S., L.E.N.), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Cell Physiology Institute, Universidad Nacional Autónoma de México, D.F., Mexico (R.A.-H., J.A.G.-S.); and Pharmaceutical Sciences, Universidade de Brasília, Brasília, Brazil (L.A.S.R.)
Rocío Alcántara-Hernández
Laboratory of Molecular and Biochemical Pharmacology (J.B.N.-V., A.R.C., F.C.-S., F.N., C.L.M.S.) and Cell Biology and Development Research Program (P.A.R.S., L.E.N.), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Cell Physiology Institute, Universidad Nacional Autónoma de México, D.F., Mexico (R.A.-H., J.A.G.-S.); and Pharmaceutical Sciences, Universidade de Brasília, Brasília, Brazil (L.A.S.R.)
Fernanda Chagas-Silva
Laboratory of Molecular and Biochemical Pharmacology (J.B.N.-V., A.R.C., F.C.-S., F.N., C.L.M.S.) and Cell Biology and Development Research Program (P.A.R.S., L.E.N.), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Cell Physiology Institute, Universidad Nacional Autónoma de México, D.F., Mexico (R.A.-H., J.A.G.-S.); and Pharmaceutical Sciences, Universidade de Brasília, Brasília, Brazil (L.A.S.R.)
Pedro A. R. Souza
Laboratory of Molecular and Biochemical Pharmacology (J.B.N.-V., A.R.C., F.C.-S., F.N., C.L.M.S.) and Cell Biology and Development Research Program (P.A.R.S., L.E.N.), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Cell Physiology Institute, Universidad Nacional Autónoma de México, D.F., Mexico (R.A.-H., J.A.G.-S.); and Pharmaceutical Sciences, Universidade de Brasília, Brasília, Brazil (L.A.S.R.)
Luiz Antonio S. Romeiro
Laboratory of Molecular and Biochemical Pharmacology (J.B.N.-V., A.R.C., F.C.-S., F.N., C.L.M.S.) and Cell Biology and Development Research Program (P.A.R.S., L.E.N.), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Cell Physiology Institute, Universidad Nacional Autónoma de México, D.F., Mexico (R.A.-H., J.A.G.-S.); and Pharmaceutical Sciences, Universidade de Brasília, Brasília, Brazil (L.A.S.R.)
J. Adolfo García-Sáinz
Laboratory of Molecular and Biochemical Pharmacology (J.B.N.-V., A.R.C., F.C.-S., F.N., C.L.M.S.) and Cell Biology and Development Research Program (P.A.R.S., L.E.N.), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Cell Physiology Institute, Universidad Nacional Autónoma de México, D.F., Mexico (R.A.-H., J.A.G.-S.); and Pharmaceutical Sciences, Universidade de Brasília, Brasília, Brazil (L.A.S.R.)
François Noël
Laboratory of Molecular and Biochemical Pharmacology (J.B.N.-V., A.R.C., F.C.-S., F.N., C.L.M.S.) and Cell Biology and Development Research Program (P.A.R.S., L.E.N.), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Cell Physiology Institute, Universidad Nacional Autónoma de México, D.F., Mexico (R.A.-H., J.A.G.-S.); and Pharmaceutical Sciences, Universidade de Brasília, Brasília, Brazil (L.A.S.R.)
Claudia Lucia Martins Silva
Laboratory of Molecular and Biochemical Pharmacology (J.B.N.-V., A.R.C., F.C.-S., F.N., C.L.M.S.) and Cell Biology and Development Research Program (P.A.R.S., L.E.N.), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Cell Physiology Institute, Universidad Nacional Autónoma de México, D.F., Mexico (R.A.-H., J.A.G.-S.); and Pharmaceutical Sciences, Universidade de Brasília, Brasília, Brazil (L.A.S.R.)
Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Research ArticleDrug Discovery and Translational Medicine
New multi-target Drugs as Potential Leads for BPH Treatment
Jéssica B. Nascimento-Viana, Aline R. Carvalho, Luiz Eurico Nasciutti, Rocío Alcántara-Hernández, Fernanda Chagas-Silva, Pedro A. R. Souza, Luiz Antonio S. Romeiro, J. Adolfo García-Sáinz, François Noël and Claudia Lucia Martins Silva
Journal of Pharmacology and Experimental Therapeutics January 1, 2016, 356 (1) 212-222; DOI: https://doi.org/10.1124/jpet.115.227066
Research ArticleDrug Discovery and Translational Medicine
New multi-target Drugs as Potential Leads for BPH Treatment
Jéssica B. Nascimento-Viana, Aline R. Carvalho, Luiz Eurico Nasciutti, Rocío Alcántara-Hernández, Fernanda Chagas-Silva, Pedro A. R. Souza, Luiz Antonio S. Romeiro, J. Adolfo García-Sáinz, François Noël and Claudia Lucia Martins Silva
Journal of Pharmacology and Experimental Therapeutics January 1, 2016, 356 (1) 212-222; DOI: https://doi.org/10.1124/jpet.115.227066
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement