Journal of Pharmacology and Experimental Therapeutics: 356 (1)

January 01, 2016; Volume 356,Issue 1

Commentary

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Editor’s Note
Kenneth D. Tew

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 1; DOI: https://doi.org/10.1124/jpet.115.230847

Minireview

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Adverse Outcome Pathways—Organizing Toxicological Information to Improve Decision Making
Stephen W. Edwards, Yu-Mei Tan, Daniel L. Villeneuve, M.E. Meek and Charlene A. McQueen

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 170-181; DOI: https://doi.org/10.1124/jpet.115.228239

Behavioral Pharmacology

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Chronic Δ⁹-Tetrahydrocannabinol during Adolescence Differentially Modulates Striatal CB1 Receptor Expression and the Acute and Chronic Effects on Learning in Adult Rats
Peter F. Weed, Catalin M. Filipeanu, Myles J. Ketchum and Peter J. Winsauer

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 20-31; DOI: https://doi.org/10.1124/jpet.115.227181
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Effects of Acute and Repeated Administration of Oxycodone and Naloxone-Precipitated Withdrawal on Intracranial Self-Stimulation in Rats
Jason M. Wiebelhaus, D. Matthew Walentiny and Patrick M. Beardsley

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 43-52; DOI: https://doi.org/10.1124/jpet.115.228940
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Lorcaserin Reduces the Discriminative Stimulus and Reinforcing Effects of Cocaine in Rhesus Monkeys
Gregory T. Collins, Lisa R. Gerak, Martin A. Javors and Charles P. France

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 85-95; DOI: https://doi.org/10.1124/jpet.115.228833
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Morphine Tolerance and Physical Dependence Are Altered in Conditional HIV-1 Tat Transgenic Mice
Sylvia Fitting, David L. Stevens, Fayez A. Khan, Krista L. Scoggins, Rachel M. Enga, Patrick M. Beardsley, Pamela E. Knapp, William L. Dewey and Kurt F. Hauser

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 96-105; DOI: https://doi.org/10.1124/jpet.115.226407

Cardiovascular

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Involvement of Potassium Channels and Calcium-Independent Mechanisms in Hydrogen Sulfide–Induced Relaxation of Rat Mesenteric Small Arteries
Elise R. Hedegaard, Anja Gouliaev, Anna K. Winther, Daniel D. R. Arcanjo, Mathilde Aalling, Nirthika S. Renaltan, Mark E. Wood, Matthew Whiteman, Nini Skovgaard and Ulf Simonsen

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 53-63; DOI: https://doi.org/10.1124/jpet.115.227017
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Endothelial Nitric Oxide Mediates Caffeine Antagonism of Alcohol-Induced Cerebral Artery Constriction
Jennifer Chang, Alexander L. Fedinec, Guruprasad Kuntamallappanavar, Charles W. Leffler, Anna N. Bukiya and Alex M. Dopico

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 106-115; DOI: https://doi.org/10.1124/jpet.115.229054
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Andrographolide Ameliorates Abdominal Aortic Aneurysm Progression by Inhibiting Inflammatory Cell Infiltration through Downregulation of Cytokine and Integrin Expression
Jun Ren, Zhenjie Liu, Qiwei Wang, Jasmine Giles, Jason Greenberg, Nader Sheibani, K. Craig Kent and Bo Liu

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 137-147; DOI: https://doi.org/10.1124/jpet.115.227934
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Angiotensin II-Induced Hypertension Is Attenuated by Reduction of Sympathetic Output in NO-Sensitive Guanylyl Cyclase 1 Knockout Mice
Kathrin Broekmans, Johannes Stegbauer, Sebastian A. Potthoff, Michael Russwurm, Doris Koesling and Evanthia Mergia

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 191-199; DOI: https://doi.org/10.1124/jpet.115.227728

Cellular and Molecular

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Regulation of Extrasynaptic GABA_A α4 Receptors by Ethanol-Induced Protein Kinase A, but Not Protein Kinase C Activation in Cultured Rat Cerebral Cortical Neurons
Stephen L. Carlson, J. Peyton Bohnsack, Vraj Patel and A. Leslie Morrow

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 148-156; DOI: https://doi.org/10.1124/jpet.115.228056

Drug Discovery and Translational Medicine

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DFL23448, A Novel Transient Receptor Potential Melastin 8–Selective Ion Channel Antagonist, Modifies Bladder Function and Reduces Bladder Overactivity in Awake Rats
Francesco A. Mistretta, Andrea Russo, Fabio Castiglione, Arianna Bettiga, Giorgia Colciago, Francesco Montorsi, Laura Brandolini, Andrea Aramini, Gianluca Bianchini, Marcello Allegretti, Silvia Bovolenta, Roberto Russo, Fabio Benigni and Petter Hedlund

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 200-211; DOI: https://doi.org/10.1124/jpet.115.228684
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New Multi-target Antagonists of α_1A-, α_1D-Adrenoceptors and 5-HT_1A Receptors Reduce Human Hyperplastic Prostate Cell Growth and the Increase of Intraurethral Pressure
Jéssica B. Nascimento-Viana, Aline R. Carvalho, Luiz Eurico Nasciutti, Rocío Alcántara-Hernández, Fernanda Chagas-Silva, Pedro A. R. Souza, Luiz Antonio S. Romeiro, J. Adolfo García-Sáinz, François Noël and Claudia Lucia Martins Silva

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 212-222; DOI: https://doi.org/10.1124/jpet.115.227066
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Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related Peptide Receptor
Licheng Shi, Sonya G. Lehto, Dawn X. D. Zhu, Hong Sun, Jianhua Zhang, Brian P. Smith, David C. Immke, Kenneth D. Wild and Cen Xu

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 223-231; DOI: https://doi.org/10.1124/jpet.115.227793

Endocrine and Diabetes

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Mitigation of Insulin Resistance by Mangiferin in a Rat Model of Fructose-Induced Metabolic Syndrome Is Associated with Modulation of CD36 Redistribution in the Skeletal Muscle
Liang Zhou, Yongquan Pan, Ritsu Chonan, Robert Batey, Xianglu Rong, Johji Yamahara, Jianwei Wang and Yuhao Li

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 74-84; DOI: https://doi.org/10.1124/jpet.115.229005

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Novel Epidermal Growth Factor Receptor Inhibitor Attenuates Angiotensin II–Induced Kidney Fibrosis
Yuanyuan Qian, Kesong Peng, Chenyu Qiu, Melissa Skibba, Yi Huang, Zheng Xu, Yali Zhang, Jie Hu, Dandan Liang, Chunpeng Zou, Yi Wang and Guang Liang

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 32-42; DOI: https://doi.org/10.1124/jpet.115.228080
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Encenicline, an α7 Nicotinic Acetylcholine Receptor Partial Agonist, Reduces Immune Cell Infiltration in the Colon and Improves Experimental Colitis in Mice
M. Salaga, L.V. Blomster, A. Piechota-Polańczyk, M. Zielińska, D. Jacenik, A.I. Cygankiewicz, W.M. Krajewska, J.D. Mikkelsen and Jakub Fichna

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 157-169; DOI: https://doi.org/10.1124/jpet.115.228205

Neuropharmacology

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Paeoniflorin Promotes Non-rapid Eye Movement Sleep via Adenosine A₁ Receptors
Chang-Rui Chen, Yu Sun, Yan-Jia Luo, Xin Zhao, Jiang-Fan Chen, Yuchio Yanagawa, Wei-Min Qu and Zhi-Li Huang

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 64-73; DOI: https://doi.org/10.1124/jpet.115.227819
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A₁ Adenosine Receptor–Mediated Inhibition of Parasympathetic Neuromuscular Transmission in Human and Murine Urinary Bladder
Timothy J. Searl, Danuta I. Dynda, Shaheen R. Alanee, Ahmed M. El-Zawahry, Kevin T. McVary and Eugene M. Silinsky

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 116-122; DOI: https://doi.org/10.1124/jpet.115.228882
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VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy
Hilary Highfield Nickols, Joannes P. Yuh, Karen J. Gregory, Ryan D. Morrison, Brittney S. Bates, Shaun R. Stauffer, Kyle A. Emmitte, Michael Bubser, Weimin Peng, Michael T. Nedelcovych, Analisa Thompson, Xiaohui Lv, Zixiu Xiang, J. Scott Daniels, Colleen M. Niswender, Craig W. Lindsley, Carrie K. Jones and P. Jeffrey Conn

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 123-136; DOI: https://doi.org/10.1124/jpet.115.226597
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Abuse-Related Neurochemical Effects of Para-Substituted Methcathinone Analogs in Rats: Microdialysis Studies of Nucleus Accumbens Dopamine and Serotonin
Julie A. Suyama, Farhana Sakloth, Renata Kolanos, Richard A. Glennon, Matthew F. Lazenka, S. Stevens Negus and Matthew L. Banks

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 182-190; DOI: https://doi.org/10.1124/jpet.115.229559

Toxicology

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Methylmercury-Dependent Increases in Fluo4 Fluorescence in Neonatal Rat Cerebellar Slices Depend on Granule Cell Migrational Stage and GABA_A Receptor Modulation
Aaron B. Bradford, Jayme D. Mancini and William D. Atchison

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 2-12; DOI: https://doi.org/10.1124/jpet.115.226761
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Pharmacological Characterization of the Edema Caused by Vitalius dubius (Theraphosidae, Mygalomorphae) Spider Venom in Rats
Thomaz A. A. Rocha-e-Silva, Alessandra Linardi, Edson Antunes and Stephen Hyslop

Journal of Pharmacology and Experimental Therapeutics January 2016, 356 (1) 13-19; DOI: https://doi.org/10.1124/jpet.115.226787

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Table of Contents

Commentary

Minireview

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Neuropharmacology

Toxicology

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