Research ArticleDrug Discovery and Translational Medicine
Semimechanistic Cell-Cycle Type–Based Pharmacokinetic/Pharmacodynamic Model of Chemotherapy-Induced Neutropenic Effects of Diflomotecan under Different Dosing Schedules
Víctor Mangas-Sanjuan, Núria Buil-Bruna, María J. Garrido, Elena Soto and Iñaki F. Trocóniz
Journal of Pharmacology and Experimental Therapeutics July 2015, 354 (1) 55-64; DOI: https://doi.org/10.1124/jpet.115.223776
Víctor Mangas-Sanjuan
Department of Engineering, Department of Pharmacy and Pharmaceutical Technology Area, University of Miguel Hernández de Elche, San Juan de Alicante, Alicante, Spain (V.M.-S.); Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Navarra, Spain (N.B.-B., M.J.G., I.F.T.); and Pharmacometrics, Pfizer, Sandwich, United Kingdom (E.S.)
Núria Buil-Bruna
Department of Engineering, Department of Pharmacy and Pharmaceutical Technology Area, University of Miguel Hernández de Elche, San Juan de Alicante, Alicante, Spain (V.M.-S.); Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Navarra, Spain (N.B.-B., M.J.G., I.F.T.); and Pharmacometrics, Pfizer, Sandwich, United Kingdom (E.S.)
María J. Garrido
Department of Engineering, Department of Pharmacy and Pharmaceutical Technology Area, University of Miguel Hernández de Elche, San Juan de Alicante, Alicante, Spain (V.M.-S.); Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Navarra, Spain (N.B.-B., M.J.G., I.F.T.); and Pharmacometrics, Pfizer, Sandwich, United Kingdom (E.S.)
Elena Soto
Department of Engineering, Department of Pharmacy and Pharmaceutical Technology Area, University of Miguel Hernández de Elche, San Juan de Alicante, Alicante, Spain (V.M.-S.); Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Navarra, Spain (N.B.-B., M.J.G., I.F.T.); and Pharmacometrics, Pfizer, Sandwich, United Kingdom (E.S.)
Iñaki F. Trocóniz
Department of Engineering, Department of Pharmacy and Pharmaceutical Technology Area, University of Miguel Hernández de Elche, San Juan de Alicante, Alicante, Spain (V.M.-S.); Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Navarra, Spain (N.B.-B., M.J.G., I.F.T.); and Pharmacometrics, Pfizer, Sandwich, United Kingdom (E.S.)
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Research ArticleDrug Discovery and Translational Medicine
Cell-Cycle Type PKPD-Based Model for Neutropenic Effects
Víctor Mangas-Sanjuan, Núria Buil-Bruna, María J. Garrido, Elena Soto and Iñaki F. Trocóniz
Journal of Pharmacology and Experimental Therapeutics July 1, 2015, 354 (1) 55-64; DOI: https://doi.org/10.1124/jpet.115.223776
Research ArticleDrug Discovery and Translational Medicine
Cell-Cycle Type PKPD-Based Model for Neutropenic Effects
Víctor Mangas-Sanjuan, Núria Buil-Bruna, María J. Garrido, Elena Soto and Iñaki F. Trocóniz
Journal of Pharmacology and Experimental Therapeutics July 1, 2015, 354 (1) 55-64; DOI: https://doi.org/10.1124/jpet.115.223776
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