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Research ArticleDrug Discovery and Translational Medicine

Semimechanistic Cell-Cycle Type–Based Pharmacokinetic/Pharmacodynamic Model of Chemotherapy-Induced Neutropenic Effects of Diflomotecan under Different Dosing Schedules

Víctor Mangas-Sanjuan, Núria Buil-Bruna, María J. Garrido, Elena Soto and Iñaki F. Trocóniz
Journal of Pharmacology and Experimental Therapeutics July 2015, 354 (1) 55-64; DOI: https://doi.org/10.1124/jpet.115.223776

Article Information

vol. 354 no. 1 55-64
DOI 
https://doi.org/10.1124/jpet.115.223776
PubMed 
25948593
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 16, 2014
  • Accepted May 5, 2015
  • Published online June 1, 2015.

Article Versions

Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Víctor Mangas-Sanjuan,
  2. Núria Buil-Bruna,
  3. María J. Garrido,
  4. Elena Soto, and
  5. Iñaki F. Trocóniz
  1. Department of Engineering, Department of Pharmacy and Pharmaceutical Technology Area, University of Miguel Hernández de Elche, San Juan de Alicante, Alicante, Spain (V.M.-S.); Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Navarra, Spain (N.B.-B., M.J.G., I.F.T.); and Pharmacometrics, Pfizer, Sandwich, United Kingdom (E.S.)
  1. Address correspondence to:
    Iñaki F. Trocóniz, Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Irunlarrea 1, 31080, Pamplona, Navarra, Spain. E-mail: itroconiz{at}unav.es
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Research ArticleDrug Discovery and Translational Medicine

Cell-Cycle Type PKPD-Based Model for Neutropenic Effects

Víctor Mangas-Sanjuan, Núria Buil-Bruna, María J. Garrido, Elena Soto and Iñaki F. Trocóniz
Journal of Pharmacology and Experimental Therapeutics July 1, 2015, 354 (1) 55-64; DOI: https://doi.org/10.1124/jpet.115.223776
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