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Research ArticleDrug Discovery and Translational Medicine

Anti-PCSK9 Antibody Pharmacokinetics and Low-Density Lipoprotein-Cholesterol Pharmacodynamics in Nonhuman Primates Are Antigen Affinity–Dependent and Exhibit Limited Sensitivity to Neonatal Fc Receptor–Binding Enhancement

Kirk R. Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun, Jared Higbee, Jie Tang, Katherine C. Matsuda, Ren Xu, Lei Zhou, Joyce C. Y. Chan, Chadwick King, Derek E. Piper, Randal R. Ketchem, Mark Leo Michaels, Simon M. Jackson and Marc W. Retter
Journal of Pharmacology and Experimental Therapeutics April 2015, 353 (1) 119-131; DOI: https://doi.org/10.1124/jpet.114.221242

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Research ArticleDrug Discovery and Translational Medicine

PCSK9- and FcRn-Binding Affinities Affect Antibody PK and PD

Kirk R. Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun, Jared Higbee, Jie Tang, Katherine C. Matsuda, Ren Xu, Lei Zhou, Joyce C. Y. Chan, Chadwick King, Derek E. Piper, Randal R. Ketchem, Mark Leo Michaels, Simon M. Jackson and Marc W. Retter
Journal of Pharmacology and Experimental Therapeutics April 1, 2015, 353 (1) 119-131; DOI: https://doi.org/10.1124/jpet.114.221242
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