Research ArticleCellular and Molecular
Δ-9,11 Modification of Glucocorticoids Dissociates Nuclear Factor-κB Inhibitory Efficacy from Glucocorticoid Response Element-Associated Side Effects
Andreas R. Baudy, Erica K. M. Reeves, Jesse M. Damsker, Christopher Heier, Lindsay M. Garvin, Blythe C. Dillingham, John McCall, Sree Rayavarapu, Zuyi Wang, Jack H. Vandermeulen, Arpana Sali, Vanessa Jahnke, Stephanie Duguez, Debra DuBois, Mary C. Rose, Kanneboyina Nagaraju and Eric P. Hoffman
Journal of Pharmacology and Experimental Therapeutics October 2012, 343 (1) 225-232; DOI: https://doi.org/10.1124/jpet.112.194340
Andreas R. Baudy
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Erica K. M. Reeves
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Jesse M. Damsker
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Christopher Heier
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Lindsay M. Garvin
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Blythe C. Dillingham
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
John McCall
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Sree Rayavarapu
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Zuyi Wang
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Jack H. Vandermeulen
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Arpana Sali
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Vanessa Jahnke
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Stephanie Duguez
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Debra DuBois
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Mary C. Rose
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Kanneboyina Nagaraju
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Eric P. Hoffman
Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (A.R.B., L.M.G., S.R., Z.W., M.C.R., K.N., E.P.H.); Center for Genetic Medicine Research, Children's National Medical Center, Washington, District of Columbia (A.R.B., C.H., L.M.G., S.R., Z.W., J.H.V., A.S., V.J., S.D., M.C.R., K.N., E.P.H.); ReveraGen BioPharma, Rockville, Maryland (E.K.M.R., J.M.D., B.C.D.); PharMac LLC, Boca Grande, Florida (J.M.); and Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (D.D.)
Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Research ArticleCellular and Molecular
Dissociative Δ-9,11 Steroids
Andreas R. Baudy, Erica K. M. Reeves, Jesse M. Damsker, Christopher Heier, Lindsay M. Garvin, Blythe C. Dillingham, John McCall, Sree Rayavarapu, Zuyi Wang, Jack H. Vandermeulen, Arpana Sali, Vanessa Jahnke, Stephanie Duguez, Debra DuBois, Mary C. Rose, Kanneboyina Nagaraju and Eric P. Hoffman
Journal of Pharmacology and Experimental Therapeutics October 1, 2012, 343 (1) 225-232; DOI: https://doi.org/10.1124/jpet.112.194340
Research ArticleCellular and Molecular
Dissociative Δ-9,11 Steroids
Andreas R. Baudy, Erica K. M. Reeves, Jesse M. Damsker, Christopher Heier, Lindsay M. Garvin, Blythe C. Dillingham, John McCall, Sree Rayavarapu, Zuyi Wang, Jack H. Vandermeulen, Arpana Sali, Vanessa Jahnke, Stephanie Duguez, Debra DuBois, Mary C. Rose, Kanneboyina Nagaraju and Eric P. Hoffman
Journal of Pharmacology and Experimental Therapeutics October 1, 2012, 343 (1) 225-232; DOI: https://doi.org/10.1124/jpet.112.194340
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement