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Research ArticleNEUROPHARMACOLOGY

Pharmacokinetic-Pharmacodynamic Modeling of the Antinociceptive Effect of Buprenorphine and Fentanyl in Rats: Role of Receptor Equilibration Kinetics

Ashraf Yassen, Erik Olofsen, Albert Dahan and Meindert Danhof
Journal of Pharmacology and Experimental Therapeutics June 2005, 313 (3) 1136-1149; DOI: https://doi.org/10.1124/jpet.104.082560

Article Information

vol. 313 no. 3 1136-1149
DOI 
https://doi.org/10.1124/jpet.104.082560
PubMed 
15701707
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received December 21, 2004
  • Accepted February 3, 2005
  • Published online May 17, 2005.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ashraf Yassen,
  2. Erik Olofsen,
  3. Albert Dahan and
  4. Meindert Danhof
  1. Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Gorlaeus Laboratory, Leiden, The Netherlands (A.Y., M.D.); and Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands (E.O., A.D.)
  1. Address correspondence to:
    Dr. Meindert Danhof, Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA Leiden, The Netherlands. E-mail: m.danhof{at}lacdr.leidenuniv.nl
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Research ArticleNEUROPHARMACOLOGY

Pharmacokinetic-Pharmacodynamic Modeling of the Antinociceptive Effect of Buprenorphine and Fentanyl in Rats: Role of Receptor Equilibration Kinetics

Ashraf Yassen, Erik Olofsen, Albert Dahan and Meindert Danhof
Journal of Pharmacology and Experimental Therapeutics June 1, 2005, 313 (3) 1136-1149; DOI: https://doi.org/10.1124/jpet.104.082560
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