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Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Importance of Amino Acids of the Central Portion of the Second Intracellular Loop of the Gastrin-Releasing Peptide Receptor for Phospholipase C Activation, Internalization, and Chronic Down-Regulation

Michael Schumann, Tomoo Nakagawa, Samuel A. Mantey, Kenji Tokita, David J. Venzon, Simon J. Hocart, Richard V. Benya and Robert T. Jensen
Journal of Pharmacology and Experimental Therapeutics November 2003, 307 (2) 597-607; DOI: https://doi.org/10.1124/jpet.103.055087

Article Information

vol. 307 no. 2 597-607
DOI 
https://doi.org/10.1124/jpet.103.055087
PubMed 
12970386
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received May 29, 2003
  • Accepted July 30, 2003
  • Published online October 21, 2003.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Michael Schumann,
  2. Tomoo Nakagawa,
  3. Samuel A. Mantey,
  4. Kenji Tokita,
  5. David J. Venzon,
  6. Simon J. Hocart,
  7. Richard V. Benya and
  8. Robert T. Jensen
  1. Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (M.S., T.N., S.A.M., K.T., R.V.B., R.T.J.), and Biostatistics and Data Management Section, National Cancer Institute, National Institutes of Health (D.J.V.), Bethesda, Maryland; and Peptide Research Laboratories, Department of Medicine, Tulane University Health Sciences Center (S.J.H.), New Orleans, Louisiana
  1. Address correspondence to:
    Dr. Robert T. Jensen, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 10, Rm. 9C-103, 10 Center Dr., MSC 1804, Bethesda, MD. E-mail: robertj{at}bdg10.niddk.nih.gov
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Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Importance of Amino Acids of the Central Portion of the Second Intracellular Loop of the Gastrin-Releasing Peptide Receptor for Phospholipase C Activation, Internalization, and Chronic Down-Regulation

Michael Schumann, Tomoo Nakagawa, Samuel A. Mantey, Kenji Tokita, David J. Venzon, Simon J. Hocart, Richard V. Benya and Robert T. Jensen
Journal of Pharmacology and Experimental Therapeutics November 1, 2003, 307 (2) 597-607; DOI: https://doi.org/10.1124/jpet.103.055087
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