Table of Contents

November 2003; 307 (2)

PERSPECTIVES IN PHARMACOLOGY

    • Joann Trejo

    Protease-Activated Receptors: New Concepts in Regulation of G Protein-Coupled Receptor Signaling and Trafficking

    J Pharmacol Exp Ther November 2003 307:437-442; published ahead of print September 9, 2003, doi:10.1124/jpet.103.052100

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • Xiaonan Han,
    • Takashi Uchiyama,
    • Penny L. Sappington,
    • Arino Yaguchi,
    • Runkuan Yang,
    • Mitchell P. Fink,
    • and Russell L. Delude

    NAD+ Ameliorates Inflammation-Induced Epithelial Barrier Dysfunction in Cultured Enterocytes and Mouse Ileal Mucosa

    J Pharmacol Exp Ther November 2003 307:443-449; published ahead of print September 15, 2003, doi:10.1124/jpet.103.056556
    • John R. Grider

    Neurotransmitters Mediating the Intestinal Peristaltic Reflex in the Mouse

    J Pharmacol Exp Ther November 2003 307:460-467; published ahead of print September 9, 2003, doi:10.1124/jpet.103.053512
    • Michael Schumann,
    • Tomoo Nakagawa,
    • Samuel A. Mantey,
    • Kenji Tokita,
    • David J. Venzon,
    • Simon J. Hocart,
    • Richard V. Benya,
    • and Robert T. Jensen

    Importance of Amino Acids of the Central Portion of the Second Intracellular Loop of the Gastrin-Releasing Peptide Receptor for Phospholipase C Activation, Internalization, and Chronic Down-Regulation

    J Pharmacol Exp Ther November 2003 307:597-607; published ahead of print September 11, 2003, doi:10.1124/jpet.103.055087
    • Jiing C. Luo,
    • Vivian Y. Shin,
    • Edgar S. L. Liu,
    • Wallace H. L. So,
    • Yi N. Ye,
    • Full Y. Chang,
    • and Chi H. Cho

    Non-Ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats

    J Pharmacol Exp Ther November 2003 307:692-698; doi:10.1124/jpet.103.055202
    • Masanori Takeeda,
    • Masanori Yamato,
    • Shinichi Kato,
    • and Koji Takeuchi

    Cyclooxygenase Isozymes Involved in Adaptive Functional Responses in Rat Stomach after Barrier Disruption

    J Pharmacol Exp Ther November 2003 307:713-719; published ahead of print September 15, 2003, doi:10.1124/jpet.103.054973

NEUROPHARMACOLOGY

    • Eric Backes and
    • Scott E. Hemby

    Discrete Cell Gene Profiling of Ventral Tegmental Dopamine Neurons after Acute and Chronic Cocaine Self-Administration

    J Pharmacol Exp Ther November 2003 307:450-459; doi:10.1124/jpet.103.054965
    • M. I. Damaj,
    • W. Kao,
    • and B. R. Martin

    Characterization of Spontaneous and Precipitated Nicotine Withdrawal in the Mouse

    J Pharmacol Exp Ther November 2003 307:526-534; doi:10.1124/jpet.103.054908
    • Min Wu,
    • Samuel S. Newton,
    • Joshua B. Atkins,
    • Changqing Xu,
    • Ronald S. Duman,
    • and Meenakshi Alreja

    Acetylcholinesterase Inhibitors Activate Septohippocampal GABAergic Neurons via Muscarinic but Not Nicotinic Receptors

    J Pharmacol Exp Ther November 2003 307:535-543; published ahead of print September 9, 2003, doi:10.1124/jpet.103.052514
    • Adam W. Hendricson,
    • Mark P. Thomas,
    • Melanie J. Lippmann,
    • and Richard A. Morrisett

    Suppression of L-Type Voltage-Gated Calcium Channel-Dependent Synaptic Plasticity by Ethanol: Analysis of Miniature Synaptic Currents and Dendritic Calcium Transients

    J Pharmacol Exp Ther November 2003 307:550-558; published ahead of print September 11, 2003, doi:10.1124/jpet.103.055137
    • D. A. Drakulich,
    • A. M. Walls,
    • M. L. Toews,
    • and T. D. Hexum

    Neuropeptide Y Receptor-Mediated Sensitization of ATP-Stimulated Inositol Phosphate Formation

    J Pharmacol Exp Ther November 2003 307:559-565; published ahead of print September 11, 2003, doi:10.1124/jpet.103.053082
    • Roh-Yu Shen

    Ethanol Withdrawal Reduces the Number of Spontaneously Active Ventral Tegmental Area Dopamine Neurons in Conscious Animals

    J Pharmacol Exp Ther November 2003 307:566-572; published ahead of print September 9, 2003, doi:10.1124/jpet.103.053371
    • Xinyu D. Li and
    • Jerry J. Buccafusco

    Effect of β-Amyloid Peptide 1-42 on the Cytoprotective Action Mediated by α7 Nicotinic Acetylcholine Receptors in Growth Factor-Deprived Differentiated PC-12 Cells

    J Pharmacol Exp Ther November 2003 307:670-675; published ahead of print September 11, 2003, doi:10.1124/jpet.103.053785
    • Shao-Rui Chen and
    • Hui-Lin Pan

    Up-Regulation of Spinal Muscarinic Receptors and Increased Antinociceptive Effect of Intrathecal Muscarine in Diabetic Rats

    J Pharmacol Exp Ther November 2003 307:676-681; published ahead of print September 9, 2003, doi:10.1124/jpet.103.055905
    • Ronald J. Tallarida,
    • Alan Cowan,
    • and Robert B. Raffa

    Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice

    J Pharmacol Exp Ther November 2003 307:699-704; doi:10.1124/jpet.103.054320
    • F. P. Monnet,
    • M. P. Morin-Surun,
    • J. Leger,
    • and L. Combettes

    Protein Kinase C-Dependent Potentiation of Intracellular Calcium Influx by σ1 Receptor Agonists in Rat Hippocampal Neurons

    J Pharmacol Exp Ther November 2003 307:705-712; doi:10.1124/jpet.103.053447
    • S. A. G. Visser,
    • D. R. H. Huntjens,
    • P. H. van der Graaf,
    • L. A. Peletier,
    • and M. Danhof

    Mechanism-Based Modeling of the Pharmacodynamic Interaction of Alphaxalone and Midazolam in Rats

    J Pharmacol Exp Ther November 2003 307:765-775; doi:10.1124/jpet.103.054510
    • Glória Queiroz,
    • Carlos Talaia,
    • and Jorge Gonçalves

    ATP Modulates Noradrenaline Release by Activation of Inhibitory P2Y Receptors and Facilitatory P2X Receptors in the Rat Vas Deferens

    J Pharmacol Exp Ther November 2003 307:809-815; published ahead of print September 9, 2003, doi:10.1124/jpet.103.054809

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • Tom Stover and
    • Mark Kester

    Liposomal Delivery Enhances Short-Chain Ceramide-Induced Apoptosis of Breast Cancer Cells

    J Pharmacol Exp Ther November 2003 307:468-475; published ahead of print September 15, 2003, doi:10.1124/jpet.103.054056

CELLULAR AND MOLECULAR

    • Katherine G. Moss,
    • Guy C. Toner,
    • Julie M. Cherrington,
    • Dirk B. Mendel,
    • and A. Douglas Laird

    Hair Depigmentation Is a Biological Readout for Pharmacological Inhibition of KIT in Mice and Humans

    J Pharmacol Exp Ther November 2003 307:476-480; published ahead of print September 9, 2003, doi:10.1124/jpet.103.052530
    • Susan R. George,
    • Gordon Y. K. Ng,
    • Samuel P. Lee,
    • Theresa Fan,
    • George Varghese,
    • Chen Wang,
    • Charles M. Deber,
    • Philip Seeman,
    • and Brian F. O'Dowd

    Blockade of G Protein-Coupled Receptors and the Dopamine Transporter by a Transmembrane Domain Peptide: Novel Strategy for Functional Inhibition of Membrane Proteins in Vivo

    J Pharmacol Exp Ther November 2003 307:481-489; published ahead of print September 11, 2003, doi:10.1124/jpet.103.053843
    • Eun Joung Kim,
    • Ki Sook Park,
    • Soo Youn Chung,
    • Yhun Yhong Sheen,
    • Dong Chuol Moon,
    • Yeun Sook Song,
    • Kyong Soon Kim,
    • Sukgil Song,
    • Yeo Pyo Yun,
    • Myung Koo Lee,
    • Ki Wan Oh,
    • Do Young Yoon,
    • and Jin Tae Hong

    Peroxisome Proliferator-Activated Receptor-γ Activator 15-Deoxy-Δ12,14-Prostaglandin J2 Inhibits Neuroblastoma Cell Growth through Induction of Apoptosis: Association with Extracellular Signal-Regulated Kinase Signal Pathway

    J Pharmacol Exp Ther November 2003 307:505-517; published ahead of print September 9, 2003, doi:10.1124/jpet.103.053876
    • Petrus J. Pauwels and
    • Francis C. Colpaert

    Ca2+ Responses in Chinese Hamster Ovary-K1 Cells Demonstrate an Atypical Pattern of Ligand-Induced 5-HT1A Receptor Activation

    J Pharmacol Exp Ther November 2003 307:608-614; published ahead of print September 11, 2003, doi:10.1124/jpet.103.055871
    • Robert E. Carraway,
    • Xianyong Gui,
    • and David E. Cochrane

    Ca2+ Channel Blockers Enhance Neurotensin (NT) Binding and Inhibit NT-Induced Inositol Phosphate Formation in Prostate Cancer PC3 Cells

    J Pharmacol Exp Ther November 2003 307:640-650; doi:10.1124/jpet.103.052688
    • Tim D. Werry,
    • Graeme F. Wilkinson,
    • and Gary B. Willars

    Cross Talk between P2Y2 Nucleotide Receptors and CXC Chemokine Receptor 2 Resulting in Enhanced Ca2+ Signaling Involves Enhancement of Phospholipase C Activity and Is Enabled by Incremental Ca2+ Release in Human Embryonic Kidney Cells

    J Pharmacol Exp Ther November 2003 307:661-669; published ahead of print September 15, 2003, doi:10.1124/jpet.103.055632
    • Erding Hu,
    • Edward Dul,
    • Chiu-Mei Sung,
    • Zunxuan Chen,
    • Robert Kirkpatrick,
    • Gui-Feng Zhang,
    • Kyung Johanson,
    • Ronggang Liu,
    • Amparo Lago,
    • Glenn Hofmann,
    • Ricardo Macarron,
    • Maite De Los Frailes,
    • Paloma Perez,
    • John Krawiec,
    • James Winkler,
    • and Michael Jaye

    Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases

    J Pharmacol Exp Ther November 2003 307:720-728; published ahead of print September 15, 2003, doi:10.1124/jpet.103.055541
    • Limen Chi and
    • Maarten E. A. Reith

    Substrate-Induced Trafficking of the Dopamine Transporter in Heterologously Expressing Cells and in Rat Striatal Synaptosomal Preparations

    J Pharmacol Exp Ther November 2003 307:729-736; doi:10.1124/jpet.103.055095
    • Isabelle Passagne,
    • Alexandre Evrard,
    • Jean-Yves Winum,
    • Philippe Depeille,
    • Pierre Cuq,
    • Jean-Louis Montero,
    • Didier Cupissol,
    • and Laurence Vian

    Cytotoxicity, DNA Damage, and Apoptosis Induced by New Fotemustine Analogs on Human Melanoma Cells in Relation to O6-Methylguanine DNA-Methyltransferase Expression

    J Pharmacol Exp Ther November 2003 307:816-823; doi:10.1124/jpet.103.051938

ENDOCRINE AND REPRODUCTIVE

    • Christian Thorkildsen,
    • Søren Neve,
    • Bjarne Due Larsen,
    • Eddi Meier,
    • and Jørgen Søberg Petersen

    Glucagon-Like Peptide 1 Receptor Agonist ZP10A Increases Insulin mRNA Expression and Prevents Diabetic Progression in db/db Mice

    J Pharmacol Exp Ther November 2003 307:490-496; published ahead of print September 15, 2003, doi:10.1124/jpet.103.051987

CARDIOVASCULAR

    • Horacio Vidrio,
    • Martha Medina,
    • Pilar González-Romo,
    • Marte Lorenzana-Jiménez,
    • Patricia Díaz-Arista,
    • and Alejandro Baeza

    Semicarbazide-Sensitive Amine Oxidase Substrates Potentiate Hydralazine Hypotension: Possible Role of Hydrogen Peroxide

    J Pharmacol Exp Ther November 2003 307:497-504; published ahead of print September 11, 2003, doi:10.1124/jpet.103.055350
    • Charles Plut,
    • Catherine Ribière,
    • Yves Giudicelli,
    • and Jean-Pierre Dausse

    Hypothalamic Leptin Receptor and Signaling Molecule Expressions in Cafeteria Diet-Fed Rats

    J Pharmacol Exp Ther November 2003 307:544-549; published ahead of print September 9, 2003, doi:10.1124/jpet.103.054726
    • Diethart Schmid,
    • Dawid L. Staudacher,
    • Hans G. Loew,
    • Paul G. Spieckermann,
    • Gerhard F. Ecker,
    • Stephan Kopp,
    • and Peter Chiba

    A Subset of Highly Effective Propafenone-Type Multidrug Resistance Modulators Lacks Effects on Cardiac Action Potential and Mechanical Twitch Parameters of Rat Papillary Muscles

    J Pharmacol Exp Ther November 2003 307:589-596; published ahead of print September 9, 2003, doi:10.1124/jpet.103.052993
    • Gabor Varbiro,
    • Ambrus Toth,
    • Antal Tapodi,
    • Zita Bognar,
    • Balazs Veres,
    • Balazs Sumegi,
    • and Ferenc Gallyas, Jr.

    Protective Effect of Amiodarone but Not N- Desethylamiodarone on Postischemic Hearts through the Inhibition of Mitochondrial Permeability Transition

    J Pharmacol Exp Ther November 2003 307:615-625; published ahead of print September 11, 2003, doi:10.1124/jpet.103.053553
    • Giuseppe Rossoni,
    • Barbara Manfredi,
    • Viviana Cavalca,
    • Roberta Razzetti,
    • Stefano Bongrani,
    • Gian Luca Polvani,
    • and Ferruccio Berti

    The Aminotetraline Derivative (±)-(R,S)-5,6-Dihydroxy-2-methylamino-1,2,3,4-tetrahydro-naphthalene Hydrochloride (CHF-1024) Displays Cardioprotection in Postischemic Ventricular Dysfunction of the Rat Heart

    J Pharmacol Exp Ther November 2003 307:633-639; published ahead of print September 15, 2003, doi:10.1124/jpet.103.054700
    • Hong Wang,
    • Li Lin,
    • Jiangang Jiang,
    • Yan Wang,
    • Zai Ying Lu,
    • J. Alyce Bradbury,
    • Fred Bjørn Lih,
    • Dao Wen Wang,
    • and Darryl C. Zeldin

    Up-Regulation of Endothelial Nitric-Oxide Synthase by Endothelium-Derived Hyperpolarizing Factor Involves Mitogen-Activated Protein Kinase and Protein Kinase C Signaling Pathways

    J Pharmacol Exp Ther November 2003 307:753-764; doi:10.1124/jpet.103.052787
    • Morten B. Thomsen,
    • Paul G. A. Volders,
    • Milan Stengl,
    • Roel L. H. M. G. Späatjens,
    • Jet D. M. Beekman,
    • Ulrike Bischoff,
    • Morten A. Kall,
    • Kristen Frederiksen,
    • Jørgen Matz,
    • and Marc A. Vos

    Electrophysiological Safety of Sertindole in Dogs with Normal and Remodeled Hearts

    J Pharmacol Exp Ther November 2003 307:776-784; doi:10.1124/jpet.103.052753

INFLAMMATION AND IMMUNOPHARMACOLOGY

    • Michitaka Shichijo,
    • Hiromi Sugimoto,
    • Koichi Nagao,
    • Hisayo Inbe,
    • Jeffrey A. Encinas,
    • Keisuke Takeshita,
    • Kevin B. Bacon,
    • and Florian Gantner

    Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Activation in Vivo Increases Blood Leukocyte Counts and Its Blockade Abrogates 13,14-Dihydro-15-keto-prostaglandin D2-Induced Eosinophilia in Rats

    J Pharmacol Exp Ther November 2003 307:518-525; published ahead of print September 15, 2003, doi:10.1124/jpet.103.055442
    • Mitsuteru Ishiwara,
    • Yasuo Aoki,
    • Hidetsugu Takagaki,
    • Michio Ui,
    • and Fumikazu Okajima

    TA-270 [4-Hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone], an Anti-Asthmatic Agent, Inhibits Leukotriene Production Induced by IgE Receptor Stimulation in RBL-2H3 Cells

    J Pharmacol Exp Ther November 2003 307:583-588; published ahead of print September 11, 2003, doi:10.1124/jpet.103.055145
    • Chantal Beumer,
    • Marty Wulferink,
    • Willem Raaben,
    • Daniëlle Fiechter,
    • Ruud Brands,
    • and Willem Seinen

    Calf Intestinal Alkaline Phosphatase, a Novel Therapeutic Drug for Lipopolysaccharide (LPS)-Mediated Diseases, Attenuates LPS Toxicity in Mice and Piglets

    J Pharmacol Exp Ther November 2003 307:737-744; doi:10.1124/jpet.103.056606
    • Norma C. Alonzo and
    • Barbara M. Bayer

    Antagonism of N-Methyl-d-aspartate Receptors Reduces the Vulnerability of the Immune System to Stress after Chronic Morphine

    J Pharmacol Exp Ther November 2003 307:793-800; published ahead of print September 9, 2003, doi:10.1124/jpet.103.053264

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    • Jeffrey C. Stevens,
    • Ronald N. Hines,
    • Chungang Gu,
    • Sevasti B. Koukouritaki,
    • Jason R. Manro,
    • Peter J. Tandler,
    • and Matthew J. Zaya

    Developmental Expression of the Major Human Hepatic CYP3A Enzymes

    J Pharmacol Exp Ther November 2003 307:573-582; published ahead of print September 15, 2003, doi:10.1124/jpet.103.054841
    • Xiaoyue Pan,
    • Tomohiro Terada,
    • Masahiro Okuda,
    • and Ken-Ichi Inui

    Altered Diurnal Rhythm of Intestinal Peptide Transporter by Fasting and Its Effects on the Pharmacokinetics of Ceftibuten

    J Pharmacol Exp Ther November 2003 307:626-632; published ahead of print September 11, 2003, doi:10.1124/jpet.103.055939
    • Jaya Bharathi Vaidyanathan and
    • Thomas Walle

    Cellular Uptake and Efflux of the Tea Flavonoid (-)Epicatechin-3-gallate in the Human Intestinal Cell Line Caco-2

    J Pharmacol Exp Ther November 2003 307:745-752; published ahead of print September 11, 2003, doi:10.1124/jpet.103.054296
    • Sangeeta Raje,
    • Jianjing Cao,
    • Amy Hauck Newman,
    • Huanling Gao,
    • and Natalie D. Eddington

    Evaluation of the Blood-Brain Barrier Transport, Population Pharmacokinetics, and Brain Distribution of Benztropine Analogs and Cocaine Using in Vitro and in Vivo Techniques

    J Pharmacol Exp Ther November 2003 307:801-808; doi:10.1124/jpet.103.053504
    • Akinobu Hamada,
    • Hideto Miyano,
    • Hiroshi Watanabe,
    • and Hideyuki Saito

    Interaction of Imatinib Mesilate with Human P-Glycoprotein

    J Pharmacol Exp Ther November 2003 307:824-828; published ahead of print September 15, 2003, doi:10.1124/jpet.103.055574

TOXICOLOGY

    • Letizia Antonilli,
    • Carmen Suriano,
    • Giovanna Paolone,
    • Aldo Badiani,
    • and Paolo Nencini

    Repeated Exposures to Heroin and/or Cadmium Alter the Rate of Formation of Morphine Glucuronides in the Rat

    J Pharmacol Exp Ther November 2003 307:651-660; published ahead of print September 15, 2003, doi:10.1124/jpet.103.055467

BEHAVIORAL PHARMACOLOGY

    • Mark D. Lindner,
    • Donald B. Hodges, Jr.,
    • John B. Hogan,
    • Anitra F. Orie,
    • Jason A. Corsa,
    • Donna M. Barten,
    • Craig Polson,
    • Barbara J. Robertson,
    • Valerie L. Guss,
    • Kevin W. Gillman,
    • John E. Starrett, Jr.,
    • and Valentin K. Gribkoff

    An Assessment of the Effects of Serotonin 6 (5-HT6) Receptor Antagonists in Rodent Models of Learning

    J Pharmacol Exp Ther November 2003 307:682-691; doi:10.1124/jpet.103.056002
    • Richard M. Allen,
    • Arthur L. Granger,
    • and Linda A. Dykstra

    The Competitive N-Methyl-d-aspartate Receptor Antagonist (-)-6-Phosphonomethyl-deca-hydroisoquinoline-3-carboxylic Acid (LY235959) Potentiates the Antinociceptive Effects of Opioids That Vary in Efficacy at the μ-Opioid Receptor

    J Pharmacol Exp Ther November 2003 307:785-792; doi:10.1124/jpet.103.055319

Erratum

  • Correction to “Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect”

    J Pharmacol Exp Ther November 2003 307:829

Cover image

Cover image expansion

Changes in mRNA levels of corticosteroid-responsive genes in liver as a function of time after injection of methylprednisolone in adrenalectomized rats. Artwork constructed by Amanda S. Almon. J Pharmacol Exp Ther 307:93–109, 2003.

« Previous | Next Issue »

This Issue

November 2003; 307 (2)
Cover
  1. PERSPECTIVES IN PHARMACOLOGY
  2. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  3. NEUROPHARMACOLOGY
  4. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  5. CELLULAR AND MOLECULAR
  6. ENDOCRINE AND REPRODUCTIVE
  7. CARDIOVASCULAR
  8. INFLAMMATION AND IMMUNOPHARMACOLOGY
  9. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  10. TOXICOLOGY
  11. BEHAVIORAL PHARMACOLOGY
  12. Erratum

Find articles in this issue containing these words:

Current Issue

  1. November 2009, 331 (2)
  1. Current Issue
  1. Alert me to new issues of JPET