Journal of Pharmacology and Experimental Therapeutics: 300 (3)

March 01, 2002; Volume 300,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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Excitotoxicity: Perspectives Based onN-Methyl-d-Aspartate Receptor Subtypes
David R. Lynch and Rodney P. Guttmann

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 717-723; DOI: https://doi.org/10.1124/jpet.300.3.717
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Structure-Functional Diversity of Human L-Type Ca²⁺Channel: Perspectives for New Pharmacological Targets
Darrell R. Abernethy and Nikolai M. Soldatov

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 724-728; DOI: https://doi.org/10.1124/jpet.300.3.724
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Role of Inflammatory Mediators in Thrombogenesis
Ronald J. Shebuski and Kenneth S. Kilgore

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 729-735; DOI: https://doi.org/10.1124/jpet.300.3.729

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Platelet-Endothelial Cell Adhesion Molecule-1-Directed Immunotargeting to Cardiopulmonary Vasculature
Arnaud Scherpereel, Jonathan J. Rome, Rainer Wiewrodt, Simon C. Watkins, David Winslow Harshaw, Sean Alder, Melpo Christofidou-Solomidou, Elliott Haut, Juan-Carlos Murciano, Marian Nakada, Steven M. Albelda and Vladimir R. Muzykantov

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 777-786; DOI: https://doi.org/10.1124/jpet.300.3.777
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Enhanced Induction of Cytochrome P450 Enzymes and CAR Binding in TNF (p55^−/−/p75^−/−) Double Receptor Knockout Mice Following Phenobarbital Treatment
Peter J. Van Ess, Mark P. Mattson and Robert A. Blouin

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 824-830; DOI: https://doi.org/10.1124/jpet.300.3.824
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NADPH-Dependent Metabolism of Estrone by Human Liver Microsomes
Anthony J. Lee, Laura H. Mills, Joseph W. Kosh, Allan H. Conney and Bao Ting Zhu

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 838-849; DOI: https://doi.org/10.1124/jpet.300.3.838
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Human Organic Anion Transporters and Human Organic Cation Transporters Mediate Renal Antiviral Transport
Michio Takeda, Suparat Khamdang, Shinichi Narikawa, Hiroaki Kimura, Yasuna Kobayashi, Toshinori Yamamoto, Seok Ho Cha, Takashi Sekine and Hitoshi Endou

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 918-924; DOI: https://doi.org/10.1124/jpet.300.3.918
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Prevention of Antibody-Mediated Elimination of Ligand-Targeted Liposomes by Using Poly(Ethylene glycol)-Modified Lipids
Wai Ming Li, Lawrence D. Mayer and Marcel B. Bally

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 976-983; DOI: https://doi.org/10.1124/jpet.300.3.976
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Unmasking the Dynamic Interplay between Intestinal P-Glycoprotein and CYP3A4
Carolyn L. Cummins, Wolfgang Jacobsen and Leslie Z. Benet

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1036-1045; DOI: https://doi.org/10.1124/jpet.300.3.1036
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Pharmacokinetic Role of P-Glycoprotein in Oral Bioavailability and Intestinal Secretion of Grepafloxacin in Vivo
Hiroaki Yamaguchi, Ikuko Yano, Hideyuki Saito and Ken-ichi Inui

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1063-1069; DOI: https://doi.org/10.1124/jpet.300.3.1063

BEHAVIORAL PHARMACOLOGY

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Serotonergic Attenuation of the Reinforcing and Neurochemical Effects of Cocaine in Squirrel Monkeys
Paul W. Czoty, Brett C. Ginsburg and Leonard L. Howell

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 831-837; DOI: https://doi.org/10.1124/jpet.300.3.831
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Daily Treatment with Diazepam Differentially Modifies Sensitivity to the Effects of γ-Aminobutyric Acid_A Modulators on Schedule-Controlled Responding in Rhesus Monkeys
Lance R. McMahon and Charles P. France

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1017-1025; DOI: https://doi.org/10.1124/jpet.300.3.1017
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Effects of μ-Opioid Agonists on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rhesus Monkeys: Role of μ-Agonist Efficacy
S. Stevens Negus and Nancy K. Mello

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1111-1121; DOI: https://doi.org/10.1124/jpet.300.3.1111

CARDIOVASCULAR

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Nitric Oxide Synthase Expression in Hypertension Induced by Inhibition of Glutathione Synthase
Xin J. Zhou, Nosratola D. Vaziri, Xiu Q. Wang, Fred G. Silva and Zoltan Laszik

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 762-767; DOI: https://doi.org/10.1124/jpet.300.3.762
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Bucindolol Exerts Agonistic Activity on the Propranolol-Insensitive State of β₁-Adrenoceptors in Human Myocardium
Andreas Bundkirchen, Klara Brixius, Birgit Bölck and Robert H. G. Schwinger

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 794-801; DOI: https://doi.org/10.1124/jpet.300.3.794
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Activation of Poly(ADP-Ribose) Polymerase Contributes to Development of Doxorubicin-Induced Heart Failure
P. Pacher, L. Liaudet, P. Bai, L. Virag, J. G. Mabley, G. Haskó and C. Szabó

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 862-867; DOI: https://doi.org/10.1124/jpet.300.3.862
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Signals of Oxidant-Induced Cardiomyocyte Hypertrophy: Key Activation of p70 S6 Kinase-1 and Phosphoinositide 3-Kinase
Victoria C. Tu, Joseph J. Bahl and Qin M. Chen

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1101-1110; DOI: https://doi.org/10.1124/jpet.300.3.1101

CELLULAR AND MOLECULAR

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Neurotoxic Mechanisms by Alzheimer's Disease-Linked N141I Mutant Presenilin 2
Yuichi Hashimoto, Takako Niikura, Yuko Ito, Yoshiko Kita, Kenzo Terashita and Ikuo Nishimoto

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 736-745; DOI: https://doi.org/10.1124/jpet.300.3.736
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Homologous Mutations Near the Junction of the Sixth Transmembrane Domain and the Third Extracellular Loop Lead to Constitutive Activity and Enhanced Agonist Affinity at all Muscarinic Receptor Subtypes
Diane J. Ford, Anthony Essex, Tracy A. Spalding, Ethan S. Burstein and John Ellis

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 810-817; DOI: https://doi.org/10.1124/jpet.300.3.810
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Inorganic Lead Activates the Mitogen-Activated Protein Kinase Kinase-Mitogen-Activated Protein Kinase-p90^RSK Signaling Pathway in Human Astrocytoma Cells via a Protein Kinase C-Dependent Mechanism
Hailing Lu, Marina Guizzetti and Lucio G. Costa

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 818-823; DOI: https://doi.org/10.1124/jpet.300.3.818
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Differential Modulation of Signaling Pathways and Apoptosis ofras-Transformed 10T1/2 Cells by the Depsipeptide FR901228
Kellie A. Fecteau, Jianxun Mei and Hwa-Chain R. Wang

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 890-899; DOI: https://doi.org/10.1124/jpet.300.3.890
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Functional Characterization of Adenosine Receptors and Coupling to ATP-Sensitive K⁺ Channels in Guinea Pig Urinary Bladder Smooth Muscle
Sujatha M. Gopalakrishnan, Steven A. Buckner, Ivan Milicic, Duncan R. Groebe, Kristi L. Whiteaker, David J. Burns, Usha Warrior and Murali Gopalakrishnan

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 910-917; DOI: https://doi.org/10.1124/jpet.300.3.910
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Distinct Pathways of Apoptosis Triggered by FTY720, Etoposide, and Anti-Fas Antibody in Human T-Lymphoma Cell Line (Jurkat Cells)
Masayuki Fujino, Xiao-Kang Li, Yusuke Kitazawa, Lei Guo, Mikiko Kawasaki, Naoko Funeshima, Takashi Amano and Seiichi Suzuki

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 939-945; DOI: https://doi.org/10.1124/jpet.300.3.939
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A Novel Neurotrophic Property of Glucagon-Like Peptide 1: A Promoter of Nerve Growth Factor-Mediated Differentiation in PC12 Cells
TracyAnn Perry, Debomoy K. Lahiri, Demao Chen, Jie Zhou, Karen T. Y. Shaw, Josephine M. Egan and Nigel H. Greig

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 958-966; DOI: https://doi.org/10.1124/jpet.300.3.958
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The Platelet-Activating Factor Receptor Activates the Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Induces Proliferation of Epidermal Cells through an Epidermal Growth Factor-Receptor-Dependent Pathway
Silvio A. Marques, Lady C. Dy, Michael D. Southall, Quiaofang Yi, Eva Smietana, Reuben Kapur, Mariangela Marques, Jeffrey B. Travers and Dan F. Spandau

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1026-1035; DOI: https://doi.org/10.1124/jpet.300.3.1026
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Induction of Apoptosis by 1,4-Benzothiazine Analogs in Mouse Thymocytes
C. Marchetti, S. Ulisse, S. Bruscoli, F. P. Russo, G. Migliorati, F. Schiaffella, M. G. Cifone, C. Riccardi and R. Fringuelli

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1053-1062; DOI: https://doi.org/10.1124/jpet.300.3.1053

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Methotrexate Exacerbates Tumor Progression in a Murine Model of Chronic Myeloid Leukemia
Colin L. Sweeney, Miechaleen D. Diers, Joel L. Frandsen, Roland Gunther, Catherine M. Verfaillie and R. Scott McIvor

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1075-1084; DOI: https://doi.org/10.1124/jpet.300.3.1075

ENDOCRINE AND REPRODUCTIVE

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Effects of 3-Phenyl-4-[[4-[2-(1-piperidinyl)ethoxy]phenyl]methyl]- 2H-1-benzopyran-7-ol (CHF 4056), a Novel Nonsteroidal Estrogen Agonist/Antagonist, on Reproductive and Nonreproductive Tissue
Elisabetta Galbiati, Paola Lorenza Caruso, Gabriele Amari, Elisabetta Armani, Silvia Ghirardi, Maurizio Delcanale and Maurizio Civelli

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 802-809; DOI: https://doi.org/10.1124/jpet.300.3.802
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Nicotine Reduces the Incidence of Type I Diabetes in Mice
J. G. Mabley, P. Pacher, G. J. Southan, A. L. Salzman and C. Szabó

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 876-881; DOI: https://doi.org/10.1124/jpet.300.3.876

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Functional Involvement of Rat Organic Anion Transporter 3 (rOat3;Slc22a8) in the Renal Uptake of Organic Anions
Maki Hasegawa, Hiroyuki Kusuhara, Daisuke Sugiyama, Kousei Ito, Shirou Ueda, Hitoshi Endou and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 746-753; DOI: https://doi.org/10.1124/jpet.300.3.746
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Effects of Tachykinin NK₁ Receptor Antagonists on the Viscerosensory Response Caused by Colorectal Distention in Rabbits
Shiho Okano, Yoshinori Ikeura and Nobuhiro Inatomi

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 925-931; DOI: https://doi.org/10.1124/jpet.300.3.925
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Peripheral Activity of a New NK₁ Receptor Antagonist TAK-637 in the Gastrointestinal Tract
Kalina Venkova, D. M. Sutkowski-Markmann and Beverley Greenwood-Van Meerveld

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1046-1052; DOI: https://doi.org/10.1124/jpet.300.3.1046

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Up-Regulation of Cyclooxygenase-2 by Inhibition of Cyclooxygenase-1: A Key to Nonsteroidal Anti-Inflammatory Drug-Induced Intestinal Damage
Akiko Tanaka, Shoko Hase, Tohru Miyazawa and Koji Takeuchi

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 754-761; DOI: https://doi.org/10.1124/jpet.300.3.754
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Leukotriene B₄ Production in Human Mononuclear Phagocytes Is Modulated by Interleukin-4-Induced 15-Lipoxygenase
Mirella Profita, Angelo Sala, Liboria Siena, Peter M. Henson, Robert C. Murphy, Alessandra Paternò, Anna Bonanno, Loredana Riccobono, Angela Mirabella, Giovanni Bonsignore and Antonio M. Vignola

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 868-875; DOI: https://doi.org/10.1124/jpet.300.3.868
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The Role of ATP-Sensitive Potassium Channels in Neutrophil Migration and Plasma Exudation
José Eduardo Da Silva-Santos, Maria Cláudia Santos-Silva, Fernando de Queiroz Cunha and Jamil Assreuy

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 946-951; DOI: https://doi.org/10.1124/jpet.300.3.946
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Close Relationship between the Platelet Activation Marker CD62 and the Granular Release of Platelet-Derived Growth Factor
Jochen Graff, Ute Klinkhardt, Valérie B. Schini-Kerth, Sebastian Harder, Nicole Franz, Steffen Bassus and Carl M. Kirchmaier

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 952-957; DOI: https://doi.org/10.1124/jpet.300.3.952

NEUROPHARMACOLOGY

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Neuroprotective Effect of Cilostazol against Focal Cerebral Ischemia via Antiapoptotic Action in Rats
Jae Moon Choi, Hwa Kyoung Shin, Ki Young Kim, Jeong Hyun Lee and Ki Whan Hong

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 787-793; DOI: https://doi.org/10.1124/jpet.300.3.787
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Effects of Individual and Concurrent Stimulation of Striatal D₁ and D₂ Dopamine Receptors on Electrophysiological and Behavioral Output from Rat Basal Ganglia
Barbara L. Waszczak, Lynn P. Martin, Heather E. Finlay, Natalie Zahr and James R. Stellar

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 850-861; DOI: https://doi.org/10.1124/jpet.300.3.850
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Reversal of Ethanol-Seeking Behavior by D1 and D2 Antagonists in an Animal Model of Relapse: Differences in Antagonist Potency in Previously Ethanol-Dependent versus Nondependent Rats
Xiu Liu and Friedbert Weiss

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 882-889; DOI: https://doi.org/10.1124/jpet.300.3.882
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Predominance of δ-Opioid-Binding Sites in the Porcine Enteric Nervous System
DeWayne Townsend and David R. Brown

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 900-909; DOI: https://doi.org/10.1124/jpet.300.3.900
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Endogenous Opioids in Dopaminergic Cell Body Regions Modulate Amphetamine-Induced Increases in Extracellular Dopamine Levels in the Terminal Regions
Christina A. Schad, Joseph B. Justice and Stephen G. Holtzman

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 932-938; DOI: https://doi.org/10.1124/jpet.300.3.932
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Protein Kinase C Modulation of Ethanol Inhibition of Glycine-Activated Current in Dissociated Neurons of Rat Ventral Tegmental Area
Liang Tao and Jiang Hong Ye

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 967-975; DOI: https://doi.org/10.1124/jpet.300.3.967
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A Structure/Activity Relationship Study on Arvanil, an Endocannabinoid and Vanilloid Hybrid
Vincenzo Di Marzo, Graeme Griffin, Luciano De Petrocellis, Ines Brandi, Tiziana Bisogno, William Williams, Mark C. Grier, Sanjitha Kulasegram, Anu Mahadevan, Raj K. Razdan and Billy R. Martin

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 984-991; DOI: https://doi.org/10.1124/jpet.300.3.984
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Determinants of Ligand Selectivity at the κ-Receptor Based on The Structure of the Orphanin FQ Receptor
Constance E. Owens and Huda Akil

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 992-999; DOI: https://doi.org/10.1124/jpet.300.3.992
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The Protein Kinase A Inhibitor H89 Acts on Cell Morphology by Inhibiting Rho Kinase
Jost Leemhuis, Stephanie Boutillier, Gudula Schmidt and Dieter K. Meyer

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1000-1007; DOI: https://doi.org/10.1124/jpet.300.3.1000
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Amphetamine Inhibits theN-Methyl-d-Aspartate Receptor-Mediated Responses by Directly Interacting with The Receptor/Channel Complex
Geng-Chang Yeh, Jin-Chung Chen, Hsiu-Chuan Tsai, Hsueh-Hsia Wu, Chao-Yu Lin, Ping-Ching Hsu and Yu-Chen Peng

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1008-1016; DOI: https://doi.org/10.1124/jpet.300.3.1008
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ς₁ Receptor Modulation of Opioid Analgesia in the Mouse
Jianfeng Mei and Gavril W. Pasternak

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1070-1074; DOI: https://doi.org/10.1124/jpet.300.3.1070
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Regulation of Corticotropin-Releasing Factor Neuronal Systems and Hypothalamic-Pituitary-Adrenal Axis Activity by Stress and Chronic Antidepressant Treatment
Steven C. Stout, Michael J. Owens and Charles B. Nemeroff

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1085-1092; DOI: https://doi.org/10.1124/jpet.300.3.1085
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Methylenedioxymethamphetamine Decreases Plasmalemmal and Vesicular Dopamine Transport: Mechanisms and Implications for Neurotoxicity
J. Paul Hansen, Evan L. Riddle, Verónica Sandoval, Jeffrey M. Brown, James W. Gibb, Glen R. Hanson and Annette E. Fleckenstein

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1093-1100; DOI: https://doi.org/10.1124/jpet.300.3.1093
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Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V_1b Receptor Antagonist
Claudine Serradeil-Le Gal, Jean Wagnon, Jacques Simiand, Guy Griebel, Colette Lacour, Gilles Guillon, Claude Barberis, Gabrielle Brossard, Philippe Soubrié, Dino Nisato, Marc Pascal, Rebecca Pruss, Bernard Scatton, Jean-Pierre Maffrand and Gérard Le Fur

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1122-1130; DOI: https://doi.org/10.1124/jpet.300.3.1122

TOXICOLOGY

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Thalidomide Modulates Nuclear Redox Status and Preferentially Depletes Glutathione in Rabbit Limb versus Rat Limb
Jason M. Hansen, Katie K. Harris, Martin A. Philbert and Craig Harris

Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 768-776; DOI: https://doi.org/10.1124/jpet.300.3.768

Errata

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Correction to “Effects of Pharmacological Agents upon a Transgenic Model of Parkinson's Disease in Drosophila melanogaster”
Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1131;
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Correction to “Interaction of the Sulfonylthiourea HMR 1833 with Sulfonylurea Receptors and Recombinant ATP-Sensitive K⁺ Channels: Comparison with Glibenclamide”
Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1132;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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