Table of Contents

March 2002; 300 (3)

PERSPECTIVES IN PHARMACOLOGY

    • David R. Lynch and
    • Rodney P. Guttmann

    Excitotoxicity: Perspectives Based onN-Methyl-d-Aspartate Receptor Subtypes

    J Pharmacol Exp Ther March 1, 2002 300:717-723; doi:10.1124/jpet.300.3.717
    • Darrell R. Abernethy and
    • Nikolai M. Soldatov

    Structure-Functional Diversity of Human L-Type Ca2+Channel: Perspectives for New Pharmacological Targets

    J Pharmacol Exp Ther March 1, 2002 300:724-728; doi:10.1124/jpet.300.3.724
    • Ronald J. Shebuski and
    • Kenneth S. Kilgore

    Role of Inflammatory Mediators in Thrombogenesis

    J Pharmacol Exp Ther March 1, 2002 300:729-735; doi:10.1124/jpet.300.3.729

CELLULAR AND MOLECULAR

    • Yuichi Hashimoto,
    • Takako Niikura,
    • Yuko Ito,
    • Yoshiko Kita,
    • Kenzo Terashita,
    • and Ikuo Nishimoto

    Neurotoxic Mechanisms by Alzheimer's Disease-Linked N141I Mutant Presenilin 2

    J Pharmacol Exp Ther March 1, 2002 300:736-745; doi:10.1124/jpet.300.3.736
    • Diane J. Ford,
    • Anthony Essex,
    • Tracy A. Spalding,
    • Ethan S. Burstein,
    • and John Ellis

    Homologous Mutations Near the Junction of the Sixth Transmembrane Domain and the Third Extracellular Loop Lead to Constitutive Activity and Enhanced Agonist Affinity at all Muscarinic Receptor Subtypes

    J Pharmacol Exp Ther March 1, 2002 300:810-817; doi:10.1124/jpet.300.3.810
    • Hailing Lu,
    • Marina Guizzetti,
    • and Lucio G. Costa

    Inorganic Lead Activates the Mitogen-Activated Protein Kinase Kinase-Mitogen-Activated Protein Kinase-p90RSK Signaling Pathway in Human Astrocytoma Cells via a Protein Kinase C-Dependent Mechanism

    J Pharmacol Exp Ther March 1, 2002 300:818-823; doi:10.1124/jpet.300.3.818
    • Kellie A. Fecteau,
    • Jianxun Mei,
    • and Hwa-Chain R. Wang

    Differential Modulation of Signaling Pathways and Apoptosis ofras-Transformed 10T1/2 Cells by the Depsipeptide FR901228

    J Pharmacol Exp Ther March 1, 2002 300:890-899; doi:10.1124/jpet.300.3.890
    • Sujatha M. Gopalakrishnan,
    • Steven A. Buckner,
    • Ivan Milicic,
    • Duncan R. Groebe,
    • Kristi L. Whiteaker,
    • David J. Burns,
    • Usha Warrior,
    • and Murali Gopalakrishnan

    Functional Characterization of Adenosine Receptors and Coupling to ATP-Sensitive K+ Channels in Guinea Pig Urinary Bladder Smooth Muscle

    J Pharmacol Exp Ther March 1, 2002 300:910-917; doi:10.1124/jpet.300.3.910
    • Masayuki Fujino,
    • Xiao-Kang Li,
    • Yusuke Kitazawa,
    • Lei Guo,
    • Mikiko Kawasaki,
    • Naoko Funeshima,
    • Takashi Amano,
    • and Seiichi Suzuki

    Distinct Pathways of Apoptosis Triggered by FTY720, Etoposide, and Anti-Fas Antibody in Human T-Lymphoma Cell Line (Jurkat Cells)

    J Pharmacol Exp Ther March 1, 2002 300:939-945; doi:10.1124/jpet.300.3.939
    • TracyAnn Perry,
    • Debomoy K. Lahiri,
    • Demao Chen,
    • Jie Zhou,
    • Karen T. Y. Shaw,
    • Josephine M. Egan,
    • and Nigel H. Greig

    A Novel Neurotrophic Property of Glucagon-Like Peptide 1: A Promoter of Nerve Growth Factor-Mediated Differentiation in PC12 Cells

    J Pharmacol Exp Ther March 1, 2002 300:958-966; doi:10.1124/jpet.300.3.958
    • Silvio A. Marques,
    • Lady C. Dy,
    • Michael D. Southall,
    • Quiaofang Yi,
    • Eva Smietana,
    • Reuben Kapur,
    • Mariangela Marques,
    • Jeffrey B. Travers,
    • and Dan F. Spandau

    The Platelet-Activating Factor Receptor Activates the Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Induces Proliferation of Epidermal Cells through an Epidermal Growth Factor-Receptor-Dependent Pathway

    J Pharmacol Exp Ther March 1, 2002 300:1026-1035; doi:10.1124/jpet.300.3.1026
    • C. Marchetti,
    • S. Ulisse,
    • S. Bruscoli,
    • F. P. Russo,
    • G. Migliorati,
    • F. Schiaffella,
    • M. G. Cifone,
    • C. Riccardi,
    • and R. Fringuelli

    Induction of Apoptosis by 1,4-Benzothiazine Analogs in Mouse Thymocytes

    J Pharmacol Exp Ther March 1, 2002 300:1053-1062; doi:10.1124/jpet.300.3.1053

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • Maki Hasegawa,
    • Hiroyuki Kusuhara,
    • Daisuke Sugiyama,
    • Kousei Ito,
    • Shirou Ueda,
    • Hitoshi Endou,
    • and Yuichi Sugiyama

    Functional Involvement of Rat Organic Anion Transporter 3 (rOat3;Slc22a8) in the Renal Uptake of Organic Anions

    J Pharmacol Exp Ther March 1, 2002 300:746-753; doi:10.1124/jpet.300.3.746
    • Shiho Okano,
    • Yoshinori Ikeura,
    • and Nobuhiro Inatomi

    Effects of Tachykinin NK1 Receptor Antagonists on the Viscerosensory Response Caused by Colorectal Distention in Rabbits

    J Pharmacol Exp Ther March 1, 2002 300:925-931; doi:10.1124/jpet.300.3.925
    • Kalina Venkova,
    • D. M. Sutkowski-Markmann,
    • and Beverley Greenwood-Van Meerveld

    Peripheral Activity of a New NK1 Receptor Antagonist TAK-637 in the Gastrointestinal Tract

    J Pharmacol Exp Ther March 1, 2002 300:1046-1052; doi:10.1124/jpet.300.3.1046

INFLAMMATION AND IMMUNOPHARMACOLOGY

    • Akiko Tanaka,
    • Shoko Hase,
    • Tohru Miyazawa,
    • and Koji Takeuchi

    Up-Regulation of Cyclooxygenase-2 by Inhibition of Cyclooxygenase-1: A Key to Nonsteroidal Anti-Inflammatory Drug-Induced Intestinal Damage

    J Pharmacol Exp Ther March 1, 2002 300:754-761; doi:10.1124/jpet.300.3.754
    • Mirella Profita,
    • Angelo Sala,
    • Liboria Siena,
    • Peter M. Henson,
    • Robert C. Murphy,
    • Alessandra Paternò,
    • Anna Bonanno,
    • Loredana Riccobono,
    • Angela Mirabella,
    • Giovanni Bonsignore,
    • and Antonio M. Vignola

    Leukotriene B4 Production in Human Mononuclear Phagocytes Is Modulated by Interleukin-4-Induced 15-Lipoxygenase

    J Pharmacol Exp Ther March 1, 2002 300:868-875; doi:10.1124/jpet.300.3.868
    • José Eduardo Da Silva-Santos,
    • Maria Cláudia Santos-Silva,
    • Fernando de Queiroz Cunha,
    • and Jamil Assreuy

    The Role of ATP-Sensitive Potassium Channels in Neutrophil Migration and Plasma Exudation

    J Pharmacol Exp Ther March 1, 2002 300:946-951; doi:10.1124/jpet.300.3.946
    • Jochen Graff,
    • Ute Klinkhardt,
    • Valérie B. Schini-Kerth,
    • Sebastian Harder,
    • Nicole Franz,
    • Steffen Bassus,
    • and Carl M. Kirchmaier

    Close Relationship between the Platelet Activation Marker CD62 and the Granular Release of Platelet-Derived Growth Factor

    J Pharmacol Exp Ther March 1, 2002 300:952-957; doi:10.1124/jpet.300.3.952

CARDIOVASCULAR

    • Xin J. Zhou,
    • Nosratola D. Vaziri,
    • Xiu Q. Wang,
    • Fred G. Silva,
    • and Zoltan Laszik

    Nitric Oxide Synthase Expression in Hypertension Induced by Inhibition of Glutathione Synthase

    J Pharmacol Exp Ther March 1, 2002 300:762-767; doi:10.1124/jpet.300.3.762
    • Andreas Bundkirchen,
    • Klara Brixius,
    • Birgit Bölck,
    • and Robert H. G. Schwinger

    Bucindolol Exerts Agonistic Activity on the Propranolol-Insensitive State of β1-Adrenoceptors in Human Myocardium

    J Pharmacol Exp Ther March 1, 2002 300:794-801; doi:10.1124/jpet.300.3.794
    • P. Pacher,
    • L. Liaudet,
    • P. Bai,
    • L. Virag,
    • J. G. Mabley,
    • G. Haskó,
    • and C. Szabó

    Activation of Poly(ADP-Ribose) Polymerase Contributes to Development of Doxorubicin-Induced Heart Failure

    J Pharmacol Exp Ther March 1, 2002 300:862-867; doi:10.1124/jpet.300.3.862
    • Victoria C. Tu,
    • Joseph J. Bahl,
    • and Qin M. Chen

    Signals of Oxidant-Induced Cardiomyocyte Hypertrophy: Key Activation of p70 S6 Kinase-1 and Phosphoinositide 3-Kinase

    J Pharmacol Exp Ther March 1, 2002 300:1101-1110; doi:10.1124/jpet.300.3.1101

TOXICOLOGY

    • Jason M. Hansen,
    • Katie K. Harris,
    • Martin A. Philbert,
    • and Craig Harris

    Thalidomide Modulates Nuclear Redox Status and Preferentially Depletes Glutathione in Rabbit Limb versus Rat Limb

    J Pharmacol Exp Ther March 1, 2002 300:768-776; doi:10.1124/jpet.300.3.768

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    • Arnaud Scherpereel,
    • Jonathan J. Rome,
    • Rainer Wiewrodt,
    • Simon C. Watkins,
    • David Winslow Harshaw,
    • Sean Alder,
    • Melpo Christofidou-Solomidou,
    • Elliott Haut,
    • Juan-Carlos Murciano,
    • Marian Nakada,
    • Steven M. Albelda,
    • and Vladimir R. Muzykantov

    Platelet-Endothelial Cell Adhesion Molecule-1-Directed Immunotargeting to Cardiopulmonary Vasculature

    J Pharmacol Exp Ther March 1, 2002 300:777-786; doi:10.1124/jpet.300.3.777
    • Peter J. Van Ess,
    • Mark P. Mattson,
    • and Robert A. Blouin

    Enhanced Induction of Cytochrome P450 Enzymes and CAR Binding in TNF (p55−/−/p75−/−) Double Receptor Knockout Mice Following Phenobarbital Treatment

    J Pharmacol Exp Ther March 1, 2002 300:824-830; doi:10.1124/jpet.300.3.824
    • Anthony J. Lee,
    • Laura H. Mills,
    • Joseph W. Kosh,
    • Allan H. Conney,
    • and Bao Ting Zhu

    NADPH-Dependent Metabolism of Estrone by Human Liver Microsomes

    J Pharmacol Exp Ther March 1, 2002 300:838-849; doi:10.1124/jpet.300.3.838
    • Michio Takeda,
    • Suparat Khamdang,
    • Shinichi Narikawa,
    • Hiroaki Kimura,
    • Yasuna Kobayashi,
    • Toshinori Yamamoto,
    • Seok Ho Cha,
    • Takashi Sekine,
    • and Hitoshi Endou

    Human Organic Anion Transporters and Human Organic Cation Transporters Mediate Renal Antiviral Transport

    J Pharmacol Exp Ther March 1, 2002 300:918-924; doi:10.1124/jpet.300.3.918
    • Wai Ming Li,
    • Lawrence D. Mayer,
    • and Marcel B. Bally

    Prevention of Antibody-Mediated Elimination of Ligand-Targeted Liposomes by Using Poly(Ethylene glycol)-Modified Lipids

    J Pharmacol Exp Ther March 1, 2002 300:976-983; doi:10.1124/jpet.300.3.976
    • Carolyn L. Cummins,
    • Wolfgang Jacobsen,
    • and Leslie Z. Benet

    Unmasking the Dynamic Interplay between Intestinal P-Glycoprotein and CYP3A4

    J Pharmacol Exp Ther March 1, 2002 300:1036-1045; doi:10.1124/jpet.300.3.1036
    • Hiroaki Yamaguchi,
    • Ikuko Yano,
    • Hideyuki Saito,
    • and Ken-ichi Inui

    Pharmacokinetic Role of P-Glycoprotein in Oral Bioavailability and Intestinal Secretion of Grepafloxacin in Vivo

    J Pharmacol Exp Ther March 1, 2002 300:1063-1069; doi:10.1124/jpet.300.3.1063

NEUROPHARMACOLOGY

    • Jae Moon Choi,
    • Hwa Kyoung Shin,
    • Ki Young Kim,
    • Jeong Hyun Lee,
    • and Ki Whan Hong

    Neuroprotective Effect of Cilostazol against Focal Cerebral Ischemia via Antiapoptotic Action in Rats

    J Pharmacol Exp Ther March 1, 2002 300:787-793; doi:10.1124/jpet.300.3.787
    • Barbara L. Waszczak,
    • Lynn P. Martin,
    • Heather E. Finlay,
    • Natalie Zahr,
    • and James R. Stellar

    Effects of Individual and Concurrent Stimulation of Striatal D1 and D2 Dopamine Receptors on Electrophysiological and Behavioral Output from Rat Basal Ganglia

    J Pharmacol Exp Ther March 1, 2002 300:850-861; doi:10.1124/jpet.300.3.850
    • Xiu Liu and
    • Friedbert Weiss

    Reversal of Ethanol-Seeking Behavior by D1 and D2 Antagonists in an Animal Model of Relapse: Differences in Antagonist Potency in Previously Ethanol-Dependent versus Nondependent Rats

    J Pharmacol Exp Ther March 1, 2002 300:882-889; doi:10.1124/jpet.300.3.882
    • DeWayne Townsend IV and
    • David R. Brown

    Predominance of δ-Opioid-Binding Sites in the Porcine Enteric Nervous System

    J Pharmacol Exp Ther March 1, 2002 300:900-909; doi:10.1124/jpet.300.3.900
    • Christina A. Schad,
    • Joseph B. Justice, Jr.,
    • and Stephen G. Holtzman

    Endogenous Opioids in Dopaminergic Cell Body Regions Modulate Amphetamine-Induced Increases in Extracellular Dopamine Levels in the Terminal Regions

    J Pharmacol Exp Ther March 1, 2002 300:932-938; doi:10.1124/jpet.300.3.932
    • Liang Tao and
    • Jiang Hong Ye

    Protein Kinase C Modulation of Ethanol Inhibition of Glycine-Activated Current in Dissociated Neurons of Rat Ventral Tegmental Area

    J Pharmacol Exp Ther March 1, 2002 300:967-975; doi:10.1124/jpet.300.3.967
    • Vincenzo Di Marzo,
    • Graeme Griffin,
    • Luciano De Petrocellis,
    • Ines Brandi,
    • Tiziana Bisogno,
    • William Williams,
    • Mark C. Grier,
    • Sanjitha Kulasegram,
    • Anu Mahadevan,
    • Raj K. Razdan,
    • and Billy R. Martin

    A Structure/Activity Relationship Study on Arvanil, an Endocannabinoid and Vanilloid Hybrid

    J Pharmacol Exp Ther March 1, 2002 300:984-991; doi:10.1124/jpet.300.3.984
    • Constance E. Owens and
    • Huda Akil

    Determinants of Ligand Selectivity at the κ-Receptor Based on The Structure of the Orphanin FQ Receptor

    J Pharmacol Exp Ther March 1, 2002 300:992-999; doi:10.1124/jpet.300.3.992
    • Jost Leemhuis,
    • Stephanie Boutillier,
    • Gudula Schmidt,
    • and Dieter K. Meyer

    The Protein Kinase A Inhibitor H89 Acts on Cell Morphology by Inhibiting Rho Kinase

    J Pharmacol Exp Ther March 1, 2002 300:1000-1007; doi:10.1124/jpet.300.3.1000
    • Geng-Chang Yeh,
    • Jin-Chung Chen,
    • Hsiu-Chuan Tsai,
    • Hsueh-Hsia Wu,
    • Chao-Yu Lin,
    • Ping-Ching Hsu,
    • and Yu-Chen Peng

    Amphetamine Inhibits theN-Methyl-d-Aspartate Receptor-Mediated Responses by Directly Interacting with The Receptor/Channel Complex

    J Pharmacol Exp Ther March 1, 2002 300:1008-1016; doi:10.1124/jpet.300.3.1008
    • Jianfeng Mei and
    • Gavril W. Pasternak

    ς1 Receptor Modulation of Opioid Analgesia in the Mouse

    J Pharmacol Exp Ther March 1, 2002 300:1070-1074; doi:10.1124/jpet.300.3.1070
    • Steven C. Stout,
    • Michael J. Owens,
    • and Charles B. Nemeroff

    Regulation of Corticotropin-Releasing Factor Neuronal Systems and Hypothalamic-Pituitary-Adrenal Axis Activity by Stress and Chronic Antidepressant Treatment

    J Pharmacol Exp Ther March 1, 2002 300:1085-1092; doi:10.1124/jpet.300.3.1085
    • J. Paul Hansen,
    • Evan L. Riddle,
    • Verónica Sandoval,
    • Jeffrey M. Brown,
    • James W. Gibb,
    • Glen R. Hanson,
    • and Annette E. Fleckenstein

    Methylenedioxymethamphetamine Decreases Plasmalemmal and Vesicular Dopamine Transport: Mechanisms and Implications for Neurotoxicity

    J Pharmacol Exp Ther March 1, 2002 300:1093-1100; doi:10.1124/jpet.300.3.1093
    • Claudine Serradeil-Le Gal,
    • Jean Wagnon,
    • Jacques Simiand,
    • Guy Griebel,
    • Colette Lacour,
    • Gilles Guillon,
    • Claude Barberis,
    • Gabrielle Brossard,
    • Philippe Soubrié,
    • Dino Nisato,
    • Marc Pascal,
    • Rebecca Pruss,
    • Bernard Scatton,
    • Jean-Pierre Maffrand,
    • and Gérard Le Fur

    Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V1b Receptor Antagonist

    J Pharmacol Exp Ther March 1, 2002 300:1122-1130; doi:10.1124/jpet.300.3.1122

ENDOCRINE AND REPRODUCTIVE

    • Elisabetta Galbiati,
    • Paola Lorenza Caruso,
    • Gabriele Amari,
    • Elisabetta Armani,
    • Silvia Ghirardi,
    • Maurizio Delcanale,
    • and Maurizio Civelli

    Effects of 3-Phenyl-4-[[4-[2-(1-piperidinyl)ethoxy]phenyl]methyl]- 2H-1-benzopyran-7-ol (CHF 4056), a Novel Nonsteroidal Estrogen Agonist/Antagonist, on Reproductive and Nonreproductive Tissue

    J Pharmacol Exp Ther March 1, 2002 300:802-809; doi:10.1124/jpet.300.3.802
    • J. G. Mabley,
    • P. Pacher,
    • G. J. Southan,
    • A. L. Salzman,
    • and C. Szabó

    Nicotine Reduces the Incidence of Type I Diabetes in Mice

    J Pharmacol Exp Ther March 1, 2002 300:876-881; doi:10.1124/jpet.300.3.876

BEHAVIORAL PHARMACOLOGY

    • Paul W. Czoty,
    • Brett C. Ginsburg,
    • and Leonard L. Howell

    Serotonergic Attenuation of the Reinforcing and Neurochemical Effects of Cocaine in Squirrel Monkeys

    J Pharmacol Exp Ther March 1, 2002 300:831-837; doi:10.1124/jpet.300.3.831
    • Lance R. McMahon and
    • Charles P. France

    Daily Treatment with Diazepam Differentially Modifies Sensitivity to the Effects of γ-Aminobutyric AcidA Modulators on Schedule-Controlled Responding in Rhesus Monkeys

    J Pharmacol Exp Ther March 1, 2002 300:1017-1025; doi:10.1124/jpet.300.3.1017
    • S. Stevens Negus and
    • Nancy K. Mello

    Effects of μ-Opioid Agonists on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rhesus Monkeys: Role of μ-Agonist Efficacy

    J Pharmacol Exp Ther March 1, 2002 300:1111-1121; doi:10.1124/jpet.300.3.1111

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • Colin L. Sweeney,
    • Miechaleen D. Diers,
    • Joel L. Frandsen,
    • Roland Gunther,
    • Catherine M. Verfaillie,
    • and R. Scott McIvor

    Methotrexate Exacerbates Tumor Progression in a Murine Model of Chronic Myeloid Leukemia

    J Pharmacol Exp Ther March 1, 2002 300:1075-1084; doi:10.1124/jpet.300.3.1075

Errata

  • Correction to “Effects of Pharmacological Agents upon a Transgenic Model of Parkinson's Disease in Drosophila melanogaster”

    J Pharmacol Exp Ther March 1, 2002 300:1131

  • Correction to “Interaction of the Sulfonylthiourea HMR 1833 with Sulfonylurea Receptors and Recombinant ATP-Sensitive K+ Channels: Comparison with Glibenclamide”

    J Pharmacol Exp Ther March 1, 2002 300:1132
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This Issue

March 2002; 300 (3)
Cover
  1. PERSPECTIVES IN PHARMACOLOGY
  2. CELLULAR AND MOLECULAR
  3. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  4. INFLAMMATION AND IMMUNOPHARMACOLOGY
  5. CARDIOVASCULAR
  6. TOXICOLOGY
  7. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  8. NEUROPHARMACOLOGY
  9. ENDOCRINE AND REPRODUCTIVE
  10. BEHAVIORAL PHARMACOLOGY
  11. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  12. Errata

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