Abstract
1. The maximum tolerated dose (intramuscular in the rabbit) of bismuth oleate (Oleo-Bi, Roche) is about 200 mgm. Bi per kilo. This dose heavily necroses the kidney.
2. A dose of 100 mgm. Bi per kilo in the form of the oleate is tolerated but is well within the range of nephro-toxicity. Tables are given of the urinary excretion of bismuth after large and small doses of Oleo-Bi.
3. The rate of excretion of this bismuth salt is somewhat variable, and rather similar to that of sodium bismuth citrate.
4. A dose of 535 mgm. per kilo of precipitated bismuth (Neo-Trepol), intramuscular in the rabbit, was lethal; a dose of 400 mgm. per kilo was tolerated but heavily nephropathic. This confirms Hopkins' tolerated dose of 400 mgm. per kilo.
5. A dose of 85 mgm. per kilo of precipitated bismuth was well tolerated but was partially nephro-toxic.
6. Tables are given of the urinary excretion of bismuth after large and small doses of Neo-Trepol. Urinary excretion of precipitated bismuth is very regular, averaging with the smallest dose (dose 85 mgm. per kilo) 1.60 mgm. per day.
7. With both precipitated bismuth and bismuth oleate, the rate of urinary excretion is less the larger the dose, and this agrees with the extent of kidney damage.
8. Evidence is adduced for an additive effect of bismuth and tartrate ions in producing the toxicity of tartrobismuthates.
Footnotes
- Received March 9, 1926.
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