Abstract

1. Ephedrine raises blood pressure in hemorrhages and in experimental shock induced by histamine, peptone, anaphylaxis, or by surgical manipulation.

2. The rise in blood pressure is permanent under favorable conditions and this effect of the drug is due to increased cardiac output and not to arterial constriction.

3. Ephedrine fails to act when the heart beat becomes impaired, or respiration ceases, or the degree of shock is too extensive, or when hemorrhage exceeds 25 per cent. It has, however, no harmful effects.