Abstract
Female rats were given 50 mg of chlorcyclizine per kg p.o. for 3, 7 or 14 days and sacrificed 24 hours after the last drug dose. Analysis of extracts from liver, kidney, lung, spleen and brain by thin-layer chromatography showed a continuous increase in the concentrations of chlorcyclizine, N-(p-chlorobenzhydryl)-piperazine (CBP, norchlorcyclizine) and of a novel metabolite, N-(p-chlorobenzhydryl)-ethylenediamine (CBED). Studies after longer intervals following a 14-day treatment revealed a rapid decline of chlorcyclizine, a slower decline of CBP and a distinctly retarded elimination of CBED. This metabolite (CBED) was also detected, besides CBP, in organs of rats given three 100 mg/kg doses of meclizine for six days. The identification of CBED was achieved by comparison with the synthetic compound.
Footnotes
- Received September 14, 1972.
- Accepted January 2, 1973.
- © 1973 by The Williams & Wilkins Co.
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