Abstract
Germine-3-monoacetate (GMA), 25 and 50 µg/ml caused a weak contraction of rat and guinea-pig ileum. It. had no effect on isolated ileum of 11-day-old rats. At 6 to 50 µg/ml, GMA potentiated the contractile response of guinea-pig ilcum to coaxial electrical stimulation and antagonized tile depressant effect of morphine. hut not of tetrodotoxin. At 25 or 50 µg/ml, GMA increased the release of acetylcholine from isolated guine-pig ileum. The results suggest that some effects of GMA on the smooth muscle may be mediated by release of acetylcholine.
Footnotes
- Received March 24, 1970.
- © 1971, by The Williams & Wilkins Company
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement