Abstract
Vanillic acid diethylamide (VAD), injected intraaortically, intravertebrally, intracarotid, or intravenously, produced increments in blood pressure and cardiac contractile force. Treatment with βTM 10 or atropine, acute cardiac denervation, or spinal transection did not alter significantly the circulatory stimulant responses to VAD injection.
Total preganglionic spinal cord blockade produced by epidural procaine injections blocked circulatory stimulant responses to intravertebral and intracarotid injection of VAD. Responses to intraaortic injection, however, were not significantly decreased.
The cardiac positive inotropic effect of VAD was suppressed by the presence of DCI, while the vasopressor responses of VAD were suppressed by the presence of phentolamine.
VAD produced substantial increases in plasma catecholamine levels. This effect, as well as the circulatory stimulant effects, was not obtained following acute bilateral adrenalectomy.
Under the conditions of the present experiments, the circulatory stimulant action of VAD, produced by whatever route of injection, is dependent on the presence of the adrenal glands.
Footnotes
- Received October 8, 1962.
- Accepted October 9, 1963.
- The Williams & Wilkins Company
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
