Abstract
By a combination of solvent extraction and fluorimetric assay, significant concentrations of tyramine have been measured in mammalian tissues. Criteria for identification of the material measured as tyramine were: (a) fluorescence properties; (b) behavior on paper and gas-liquid chromatography and (c) enzymatic conversion to p-hydroxyphenylacetic acid. The amine is present in amounts of 1 to 6 µg/g in various parts of the central nervous system of rat, rabbit, dog and cat. The highest concentrations were in the brain stem and spinal cord.
Footnotes
- Received December 28, 1962.
- Accepted February 8, 1963.
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