Abstract
Sodium salicylate was found to decrease the time necessary to effect respiratory arrest for ether and chloroform anesthesia in rats. In addition it was found to decrease the time to respiratory arrest due to hypoxia in animals receiving 95% N2O-5% O2 and 91% N2O-9% O2 mixtures. A dose-response relationship, resulting in decreased time to respiratory arrest with increased salicylate dosage, was seen to exist for ether anesthesia. Sodium salicylate, however, was found to have no effect on the interval needed to elicit respiratory arrest in animals receiving constant intravenous infusion of sodium pentobarbital. Since increased salicylate dosages increased oxygen consumption, the effect of salicylate on the inhalation anesthetics was interpreted as being primarily caused by the increased respiration seen in these animals.
Footnotes
- Received July 10, 1962.
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