Abstract
Iproniazid, administered intraperitoneally to rats, readily entered the brain and other tissues of the body, reaching a maximum concentration within 1 hour after administration of the drug. The concentration of the compound fell steadily until at 24 hours none could be detected in the brain, liver, or muscle. The drug persisted in trace amounts in the plasma for 48 hours although no storage depots could be discovered. The major end product, isonicotinic acid, was found in each of the tissues above in concentrations that paralleled the levels of the parent drug and again no storage depot could be found.
MAO inhibition was initiated within the first half-hour after the dose was administered, and was essentially complete for 5 to 6 days, long after the last trace of drug or metabolite had disappeared.
Footnotes
- Received June 6, 1958.
- © 1958, by The Williams & Wilkins Company
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