Abstract
It has been demonstrated that hepatotoxicity can be evaluated simply and practically by the prolongation of pentobarbital sleeping time. The data can be resolved into the standard doseresponse curve, thus permitting an estimate of the ED50 for production of hepatic damage.
In hepatotoxic potency, the increasing order of toxicity was: 1,1,1-trichloroethane; tetrachloroethylene; trichloroethylene; sym-tetrachloroethane; 1,1,2-trichloroethane; chloroform; carbon tetrachloride.
The lethal potency of the compounds increased as follows: tetrachloroethylene; carbon tetrachloride; 1,1,1-trichloroethane; trichloroethylene; sym-tetrachloroethane; chloroform; 1,1,2-trichloroethane.
There was a lack of correlation between the dose causing liver damage and the dose causing death.
Footnotes
- Received February 10, 1958.
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