Abstract

Hexahydro-1-azepinepropionamidoxime dihydrochloricle (Su-4029) has been studied for its effects on the cardiovascular system of the dog. A single intravenous dose of 30 mgm./kgm. of this compound lowered the arterial pressure of neurogenie and renal hypertensive dogs while not notably affecting the blood pressure of normotensive dogs. However, in normotensive animals 30 mgm./kgm. of Su-4029, given intravenously, eliminated the severe hypertension elicited by doses of amphetamine and ephedrine and also markedly antagonized carotid occlusion reflex pressor responses. These antihypertensive effects were slow in onset and lasted for approximately 2 to 6 weeks following single injections. Su-4029 was orally active and had a cumulative action when given in small daily doses. Su-4029 is neither an adrenergic nor a ganglionic blocking agent. One site of action of Su-4029 is the sympathetic efferent periphery although this will not explain all the actions of this compound. Su-4029 produces marked sympathetic-like effects of rapid onset and relatively short duration and it is suggested that these effects may reflect the onset of the primary alterations which are responsible for the protracted antihypertension seen after Su-4029 administration.