Abstract
The renal tubular excretion of tolazoline (Priscoline) in dogs was found to be resistant to inhibition by a basic cyanine dye (# 863) which readily inhibits the renal tubular excretion of N1-methylicotinamide (NMN) and tetraethylammonium (TEA).
The renal tubular transport of NMN was readily and reversibly inhibited by a simultaneous infusion of Priscoline in experiments involving the renal portal circulation of the chicken.
Priscoline itself was shown to be excreted by the renal tubules of the chicken, suggesting that its ability to depress the simultaneous tubular transport of NMN is based on competition for a common transport system.
These and previous findings in this and other laboratories indicate that NMN, TEA, Darstine and Priscoline are all excreted by the same tubular transport system for which the latter two compounds have a relatively higher affinity.
Priscoline and its N-methyl derivative were found to be approximately equipotent in their ability to depress the tubular transport of NMN in the chicken.
Footnotes
- Received October 11, 1957.
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